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Altered B cells found in whole blood gene expression in adolescent CFS
Research abstract Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival, by Chinh Bkrong Nguyen, Lene Alsøe, Jessica M. Lindvall, Dag Sulheim, Even Fagermoen, Anette Winger, Mari Kaarbø, Hilde … Continue reading
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Tagged adolescents, B cells, gene expression, NorCAPITAL project, teenagers
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CFS and the immune system
Review summary: Chronic fatigue syndrome and the immune system: Where are we now?, by Fane Kojo Fosu Mensaha, Amolak Singh Bansal, Brian Ford, Geraldine Cambridge in Neurophysiologie Clinique/Clinical Neurophysiology [Available online 12 April 2017] Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterised by multiple … Continue reading
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Tagged B cells, Brian Ford, cytokines, Dr Amolak Bansal, Fane Fosu Mensaha, Geraldine Cambridge, immune system, NK cells
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B-cell function in patients with ME/CFS
Research summary: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous condition of unknown etiology characterized by multiple symptoms including fatigue, post-exertional malaise and cognitive impairment, lasting for at least 6 months. Recently, two clinical trials of B-cell depletion therapy with rituximab (anti-CD20) reported convincing … Continue reading
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Tagged B cells, flow cytometry, rituximab
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B cells in the immune systems of people with CFS
Research abstract Limited immunological changes have been previously reported in B cell phenotype in Chronic Fatigue Syndrome (CFS) patients, so there is no clear established role of B cells in the pathophysiology of CFS patients. The aim of this study … Continue reading
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Tagged B cells, Dr Sonja Marshall Gradisnik, Griffith University, immune dysfunction
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Rituximab UK trial update
Invest in ME have now raised £57,000 for their UK rituximab trial from a variety of organisations and individuals and can begin the first phase. The UCL team is working on a study to confirm and expand Dr Bansal’s B cell results … Continue reading
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Tagged B cells, Dr AS Bansal, Invest in ME, Matrix project, ME Association, Prof Jonathan Edwards, rituximab
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