Tag Archives: brain dysfunction

Brain function characteristics of CFS

Research abstract: Brain function characteristics of chronic fatigue syndrome: A task fMRI study, by Zack Y Shan, Kevin Finegan, Sandeep Bhutab, Timothy Ireland, Donald R Staines, Sonya M.Marshall-Gradisnik, Leighton R.Barnden in NeuroImage: Clinical Vol 19, 2018, Pages 279-286 Highlights CFS … Continue reading

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Infection elicited autoimmunity & ME/CFS: an explanatory model

Hypothesis and Theory article: Infection elicited autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: an explanatory model, by Jonas Blomberg, Carl-Gerhard Gottfries, Amal Elfaitouri, Muhammad Rizwan and Anders Rosén in Front. Immunol., 15 February 2018 Myalgic encephalomyelitis (ME) often also called chronic fatigue … Continue reading

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Decreased connectivity & increased BOLD complexity in the default mode network in CFS

Research abstract: Decreased connectivity and increased BOLD complexity in the default mode network in individuals with chronic fatigue syndrome, by ZY Shan, K Finegan, S Bhuta, T Ireland, DR Staines, SM Marshall-Gradisnik, LR Barnden in Brain Connect. 2017 Nov 20 … Continue reading

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Brain & spinal fluid abnormalities in CFS are not affected by psychiatric comorbidity

Research highlights: As a group, CFS patients have higher brain ventricular lactate, more abnormal spinal fluid results, lower brain GSH, and reduced cerebral blood flow relative to healthy sedentary controls Psychiatric comorbidity does not influence any of these potential biological … Continue reading

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Neural consequences of PEM in ME/CFS

Research abstract: Highlights: Acute exercise affects symptoms, cognitive performance and brain function in ME/CFS. Symptom provocation by exercise is a useful model to study post-exertion malaise. Objective neurophysiological evidence of the phenomenon of post-exertion malaise. Post exertion malaise is one … Continue reading

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Brain scan shows altered connectivity between different regions of the brain in CFS

Research abstract: Studies using arterial spin labelling (ASL) have shown that individuals with chronic fatigue syndrome (CFS) have decreased regional cerebral blood flow, which may be associated with changes in functional neural networks. Indeed, recent studies indicate disruptions in functional … Continue reading

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Six year study of abnormal brain changes in ME/CFS

ME Australia blog post, by  Sasha Nimmo, 12 July 2016: Six year study of abnormal brain changes in chronic fatigue syndrome patients An Australian six year study evaluating progressive brain changes associated with chronic fatigue syndrome (Fukuda and Canadian Consensus … Continue reading

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Brain white matter abnormalities in ME/CFS

ME Research UK research article, by Dr Neil Abbot, 25 May 2016: White matter abnormalities Most studies in ME/CFS are cross-sectional in nature – researchers look at patients and controls at one point in time and make comparisons between the … Continue reading

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Progressive brain changes in patients with CFS

Research abstract: PURPOSE: To examine progressive brain changes associated with chronic fatigue syndrome (CFS). MATERIALS AND METHODS: We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same … Continue reading

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Abnormal blood flow & connectivity found in ME/CFS brains

Research abstract: Although altered resting-state functional connectivity is a characteristic of many chronic pain conditions it has not yet been evaluated in patients with chronic fatigue. Our objective was to investigate the association between fatigue and altered resting-state functional connectivity … Continue reading

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