Tag Archives: Central Nervous System

Hypothesis: Broken connections: the evidence for neuroglial failure in ME/CFS

Broken Connections: The evidence for neuroglial failure in ME/CFS, by Herbert Renz-Polster, MD, Dorothee Bienzle, PhD 31 Aug 2021 [doi:10.31219/osf.io/ef3n4]   Review abstract: In spite of decades of research, the pathobiology of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) is still … Continue reading

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Sex-based differences in plasma autoantibodies to CNS proteins in Gulf War veterans versus healthy & symptomatic controls

Sex-based differences in plasma autoantibodies to Central Nervous System proteins in Gulf War veterans versus healthy and symptomatic controls, by Mohamed B Abou-Donia, Maxine H Krengel, Elizabeth S Lapadula, Clara G Zundel, Jessica LeClair, Joseph Massaro, Emily Quinn, Lisa A … Continue reading

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Using plasma autoantibodies of Central Nervous System proteins to distinguish veterans with Gulf War Illness from healthy & symptomatic controls

Using plasma autoantibodies of Central Nervous System proteins to distinguish veterans with Gulf War Illness from healthy and symptomatic controls, by Mohamed B Abou-Donia, Elizabeth S Lapadula, Maxine H Krengel, Emily Quinn, Jessica LeClair, Joseph Massaro, Lisa A Conboy, Efi Kokkotou, … Continue reading

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Processing of Laser-Evoked Potentials in patients with Chronic Whiplash-Associated Disorders, CFS & healthy controls: a case–control study

Processing of Laser-Evoked Potentials in patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and healthy controls: a case–control study, by Lisa Goudman, PhD, Liesbeth Daenen, PhD, Andre Mouraux, PhD, Jo Nijs, PhD, Patrick Cras, PhD, Nathalie Roussel, PhD, Maarten Moens, … Continue reading

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Advances in understanding the pathophysiology of CFS

Advances in understanding the pathophysiology of Chronic Fatigue Syndrome, by Anthony L Komaroff in JAMA [Preprint July 5, 2019]   Viewpoint extracts: When does an illness become a disease? When the underlying biological abnormalities that cause the symptoms and signs of the … Continue reading

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The putative glymphatic signature of CFS

The putative glymphatic signature of CFS: A new view on the disease pathogenesis and therapy, by Peter Wostyn, Peter Paul De Deyn in Medical Hypotheses Sept 2018, Vol 118, Pages 142–145 Abstract: The underlying pathophysiology of chronic fatigue syndrome remains incompletely understood and there … Continue reading

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Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with CFS

Research abstract: Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome, by MA Zinn, ML Zinna, I Valencia, LA Jason, JG Montoya in Biological Psychology Vol 136, July 2018, Pages 87-99 We investigated central fatigue in 50 patients … Continue reading

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Transient Receptor Potential Ion channels in the etiology & pathomechanism of CFS/ME

Research abstract: Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, by Donald Staines, S Du Preez, H Cabanas, C Balinas, N Eaton, R Passmore, R Maksoud, J Redmayne, S Marshall-Gradisnik in  International Journal … Continue reading

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Glial cell inhibitors: the next sleep drugs for FM and ME/CFS?

Health Rising blog post, by Cort Johnson, 15 September: Glial Cell Inhibitors: The Next Sleep Drugs for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?   Glia: The Forgotten Brain Cell Sleep disturbances and severe stress as glial activators: key targets for … Continue reading

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Inflammation correlates with symptoms in CFS

Research overview abstract: Inflammation correlates with symptoms in chronic fatigue syndrome, by Anthony L Komaroff in PNAS August 15, 2017 It is not unusual for patients who say they are sick to have normal results on standard laboratory testing. The physician … Continue reading

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