Tag Archives: Central Nervous System

The putative glymphatic signature of CFS

The putative glymphatic signature of CFS: A new view on the disease pathogenesis and therapy, by Peter Wostyn, Peter Paul De Deyn in Medical Hypotheses Sept 2018, Vol 118, Pages 142–145 Abstract: The underlying pathophysiology of chronic fatigue syndrome remains incompletely understood and there … Continue reading

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Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with CFS

Research abstract: Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome, by MA Zinn, ML Zinna, I Valencia, LA Jason, JG Montoya in Biological Psychology Vol 136, July 2018, Pages 87-99 We investigated central fatigue in 50 patients … Continue reading

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Glial cell inhibitors: the next sleep drugs for FM and ME/CFS?

Health Rising blog post, by Cort Johnson, 15 September: Glial Cell Inhibitors: The Next Sleep Drugs for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?   Glia: The Forgotten Brain Cell Sleep disturbances and severe stress as glial activators: key targets for … Continue reading

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Inflammation correlates with symptoms in CFS

Research overview abstract: Inflammation correlates with symptoms in chronic fatigue syndrome, by Anthony L Komaroff in PNAS August 15, 2017 It is not unusual for patients who say they are sick to have normal results on standard laboratory testing. The physician … Continue reading

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Central nervous system findings in CFS

Review abstract: CNS findings in chronic fatigue syndrome and a neuropathological case report Kimberly Ferrero, Mitchell Silver, Alan Cocchetto, Eliezer Masliah, Dianne Langford in Journal of Investigative Medicine Vol 65 Issue 4 [published 6 April 2017] Chronic fatigue syndrome (CFS) is characterized as a persistent, debilitating complex disorder of unknown … Continue reading

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ME/CFS studies link autonomic nervous system problems to brain

Health rising blog post, by Cort Johnson, 3 Feb 2017: Chronic Fatigue Syndrome Studies Link Autonomic Nervous System Problems to Brain Dr. Barnden of the National Centre for NeuroImmnology and Emerging Diseases (NCNED) in Griffith University, Australia has been doing … Continue reading

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Roles of the right dorsolateral prefrontal cortex during physical fatigue: a magnetoencephalographic study

Research abstract: Background: A regulation system in the central nervous system plays an important role in controlling physical performance during physical fatigue. Purpose: To clarify the neural mechanisms of this regulation system during physical fatigue using magnetoencephalography (MEG) and a … Continue reading

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Immune activation in the central nervous system of ME/CFS found by cytokine network analysis of cerebrospinal fluid

Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading

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Brain-derived neurotrophic factor concentration may not be depressed in CFS

Research abstract: Due to its effect on the central nervous system, brain-derived neurotrophic factor (BDNF) has been hypothesized to be involved in a number of neurodegenerative and psychiatric disorders. Recently, BDNF was also reported to be significantly lower in patients … Continue reading

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A review of grey matter volume research in CFS

Review article abstract: Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by profound fatigue with uncertain pathologic mechanism. Neuroimage may be an important key to unveil the central nervous system (CNS) mechanism in CFS. Although most of … Continue reading

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