Tag Archives: CNS

The putative glymphatic signature of CFS

The putative glymphatic signature of CFS: A new view on the disease pathogenesis and therapy, by Peter Wostyn, Peter Paul De Deyn in Medical Hypotheses Sept 2018, Vol 118, Pages 142–145 Abstract: The underlying pathophysiology of chronic fatigue syndrome remains incompletely understood and there … Continue reading

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Inflammation correlates with symptoms in CFS

Research overview abstract: Inflammation correlates with symptoms in chronic fatigue syndrome, by Anthony L Komaroff in PNAS August 15, 2017 It is not unusual for patients who say they are sick to have normal results on standard laboratory testing. The physician … Continue reading

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Central nervous system findings in CFS

Review abstract: CNS findings in chronic fatigue syndrome and a neuropathological case report Kimberly Ferrero, Mitchell Silver, Alan Cocchetto, Eliezer Masliah, Dianne Langford in Journal of Investigative Medicine Vol 65 Issue 4 [published 6 April 2017] Chronic fatigue syndrome (CFS) is characterized as a persistent, debilitating complex disorder of unknown … Continue reading

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Roles of the right dorsolateral prefrontal cortex during physical fatigue: a magnetoencephalographic study

Research abstract: Background: A regulation system in the central nervous system plays an important role in controlling physical performance during physical fatigue. Purpose: To clarify the neural mechanisms of this regulation system during physical fatigue using magnetoencephalography (MEG) and a … Continue reading

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Immune activation in the central nervous system of ME/CFS found by cytokine network analysis of cerebrospinal fluid

Research abstract: Myalgic encephalomyelitis/chronic fatigue syndrome is an unexplained debilitating disorder that is frequently associated with cognitive and motor dysfunction. We analyzed cerebrospinal fluid from 32 cases, 40 subjects with multiple sclerosis and 19 normal subjects frequency-matched for age and … Continue reading

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Brain-derived neurotrophic factor concentration may not be depressed in CFS

Research abstract: Due to its effect on the central nervous system, brain-derived neurotrophic factor (BDNF) has been hypothesized to be involved in a number of neurodegenerative and psychiatric disorders. Recently, BDNF was also reported to be significantly lower in patients … Continue reading

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Human herpesvirus 6 and the nervous system

Human herpesvirus (HHV)-6 is a β-herpesvirus that infects most infants by 2 years of age and persists in a variety of host cells after primary infection, with intermittent reactivation typically during periods of immunosuppression. HHV-6 has two closely related species, … Continue reading

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Lixdexamfetamine dimesylate helps functioning, fatigue and pain in CFS subgroup

A drug commonly used for ADHD (Attention deficit hyperactivity disorder) has been trialled by JL Young in the USA.  Lixdexamfetamine dimesylate is in the amphetamine family and is rapidly absorbed into the body and converted to dextroamphetamine, which is responsible … Continue reading

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