Tag Archives: gene expression

The expression signature of very long non-coding RNA in ME/CFS

The expression signature of very long non-coding RNA in myalgic encephalomyelitis/ chronic fatigue syndrome, by Chin-An Yang, Sandra Bauer, Yu-Chen Ho, Franziska Sotzny, Jan-Gowth Chang, Carmen Scheibenbogen in Journal of Translational Medicine 2018 16:231 [Published: 17 August 2018] Research abstract: Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is … Continue reading

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Altered B cells found in whole blood gene expression in adolescent CFS

Research abstract Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival, by Chinh Bkrong Nguyen, Lene Alsøe, Jessica M. Lindvall, Dag Sulheim, Even Fagermoen, Anette Winger, Mari Kaarbø, Hilde … Continue reading

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Genes, mitochondria, autoimmunity & CFS: Prof Alan Light’s research

Health rising blog post, by Cort Johnson, 23 Feb 2017: Genes, Mitochondria, Autoimmunity and Chronic Fatigue Syndrome: The Alan Light Talk Dr. Light has said that he wants to do for fatigue what researchers have done for pain; that is … Continue reading

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A systematic review of the association between fatigue & genetic polymorphisms

Review abstract: Fatigue is one of the most common and distressing symptoms, leading to markedly decreased quality of life among a large subset of patients with a variety of disorders. Susceptibility to fatigue may be influenced by genetic factors including … Continue reading

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Mitochondrial proteins as possible biomarkers for subgroups of CFS

Research abstract: Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by unexplained fatigue not improved by rest. An area of investigation is the likely connection of CFS with defective mitochondrial function. In a previous work, we investigated the proteomic salivary profile … Continue reading

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Protein kinase gene dysfunction in severe CFS/ME

Research abstract: Background: The etiology and pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are unknown. However, natural killer (NK) cell dysfunction, in particular reduced NK cytotoxic activity, is a consistent finding in CFS/ME patients. Previous research has reported significant changes … Continue reading

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Gene expression factor analysis used to differentiate CFS, FM and depression

Research abstract: OBJECTIVE: To determine if independent candidate genes can be grouped into meaningful biologic factors, and whether these factors are associated with the diagnosis of chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS), while controlling for comorbid depression, sex, … Continue reading

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MicroRNAs as potential biomarkers in ME/CFS

ME Research UK comments on recent research: MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME), by RD Petty, NE McCarthy, R Le Dieu, J R … Continue reading

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Potential diagnostic biomarkers in Natural Killer cells of patients with CFS/ ME

Research abstract: BACKGROUND: Chronic Fatigue Syndrome (CFS/ME) is a complex multisystem disease of unknown aetiology which causes debilitating symptoms in up to 1% of the global population. Although a large cohort of genes have been shown to exhibit altered expression … Continue reading

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Prof George Davey Smith calls for large scale ME/CFS genetic studies

Prof George Davey Smith, a clinical epidemiologist at the university of Bristol, says there is a need for large scale genetic studies of ME/CFS as it is not possible to draw accurate conclusions from small scale studies. Simon McGrath reports on Prof … Continue reading

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