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COVID-19 (& ME/CFS?): a methyl-group assault?
COVID-19: A methyl-group assault? by Andrew McCaddon, Björn Regland in Medical Hypotheses Vol 149, Apr 2021, 110543 [ doi.org/10.1016/j.mehy.2021.110543] Research abstract: The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to ‘long-COVID’ – an increasingly recognized complication … Continue reading →
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Tagged Andrew McCaddon, Björn Regland, folate, metabolism, methylation status, oxidative stress, Vitamin B12
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Pathological mechanisms underlying ME/CFS
Pathological mechanisms underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, by Daniel Missailidis, Sarah Annesley, Paul Fisher in Preprints [Published online: 16 July 2019] doi: 10.20944/preprints201907.0196.v1 Review abstract The underlying molecular basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is not well understood. … Continue reading →
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Tagged Daniel Missailidis, diagnosis, Gut microbiota research, immune system, inflammation, metabolism, mitochondria, Paul Fisher, Sarah Annesley, signaling
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Genetic predisposition for immune system, hormone, & metabolic dysfunction in ME/CFS
Genetic predisposition for immune system, hormone, and metabolic dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: a pilot study, by Melanie Perez, Rajeev Jaundoo, Kelly Hilton, Ana Del Alamo, Kristina Gemayel, Nancy G. Klimas, Travis J A Craddock and Lubov Nathanson in … Continue reading →
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Tagged Ana Del Alamo, Dr Nancy Klimas, genetic predisposition, hormone genes, immune system, Kelly Hilton, Kristina Gemayel, Lubov Nathanson, Melanie Perez, metabolism, Rajeev Jaundoo, single-nucleotide polymorphism, SNPs, Travis JA Craddock
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Metabolic features & regulation of the healing cycle – a new model for chronic disease pathogenesis & treatment
Metabolic features and regulation of the healing cycle – a new model for chronic disease pathogenesis and treatment, by Robert K Naviaux in Mitochondrion [Available online 9 August 2018] This article presents a hypothesis of chronic diseases including ME/CFS Highlights for … Continue reading →
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Tagged cell danger response, Dr Robert Naviaux, healing cycle, hypothesis, metabolic signaling, metabolism
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ME/CFS – Metabolic disease or disturbed homeostasis?
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis? by Erifili Hatziagelaki, Maria Adamaki, Irene Tsilioni, George Dimitriadis and Theoharis C Theoharides in Journal of Pharmacology and Experimental Therapeutics August 3, 2018, jpet.118.250845 Research article abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease characterized by debilitating fatigue, lasting … Continue reading →
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Tagged disturbed homeostasis, Erifili Hatziagelaki, George Dimitriadis, inflammation, Irene Tsilioni, Maria Adamaki, mast cells, metabolism, Theoharis C Theoharides
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Viruses and CFS: statement by Prof Robert Naviaux
Open Medicine Foundation blog post, 9 Sep 2016: Viruses and CFS: Statements by Ron Davis and Bob Naviaux Dr Bob Naviaux: Question – Many ME/CFS experts have improved the symptoms in some patients by treating with antivirals and Ampligen (polyIC double … Continue reading →
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Tagged ampligen, antiviral therapy, Dr Robert Naviaux, metabolism, Open Medicine Foundation, viruses
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The study of metabolism important for CFS research
Research abstract Chronic fatigue syndrome (CFS) is a poorly understood condition that presents as long-term physical and mental fatigue with associated symptoms of pain and sensitivity across a broad range of systems in the body. The poor understanding of the … Continue reading →
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Tagged metabolism, metabolomics, mitochondria, oxidative stress
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