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Tag Archives: pro-inflammatory cytokines
Poor sleep quality, greater circulating pro-inflammatory cytokines & severity & frequency of CFS/ME
Research highlights: Sleep quality, inflammation, and CFS/ME symptoms were analyzed. Poor sleep quality predicted pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Worse sleep quality related to greater fatigue severity and daily interference. Worse sleep quality related to more severe and frequent … Continue reading
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Tagged Daniel L Hall, Dr Nancy Klimas, M. Fletcher, Michael H. Antoni, pro-inflammatory cytokines, sleep quality, women
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TRYCATS in CFS, Alzheimer’s disease and schizophrenia
Article abstract: Many if not all chronic medical, neurodegenerative and neuroprogressive illnesses are characterised by chronic immune activation, oxidative and nitrosative stress (O&NS) and systemic inflammation. These environmental factors notably elevated pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase (IDO) leading to an upregulated … Continue reading
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Tagged ATP, Gerwyn Morris, kynurenic acid, Michael Maes, neuro-immune illness, NMDA antagonists, pro-inflammatory cytokines, TRYCAT, tryptophan catabolites
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Central pathways causing fatigue in CFS
Article abstract Background The genesis of severe fatigue and disability in people following acute pathogen invasion involves the activation of Toll-like receptors followed by the upregulation of proinflammatory cytokines and the activation of microglia and astrocytes. Many patients suffering from … Continue reading
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Tagged auto-immune, fatigue, neuro-inflammatory, oxidative stress, pro-inflammatory cytokines
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Neuro-immune pathophysiology of fatigue
Research abstract Many patients with systemic immune-inflammatory and neuro-inflammatory disorders, including depression, rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s disease, cancer, cardiovascular disorder, Parkinson’s disease, multiple sclerosis, stroke, and chronic fatigue syndrome/myalgic encephalomyelitis, endure pathological levels of fatigue. The aim of … Continue reading
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Tagged fatigue, neuro-immune illness, O&NS, Oxidative and nitrosative stress, pro-inflammatory cytokines
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Viruses and cytokines in ME
Research abstract Myalgic encephalomyelitis (ME) is a polymorphic clinical entity. In some patients, chronic infection with Epstein–Barr virus (EBV), human herpesvirus 6 (HHV-6), and human herpesvirus 7 (HHV-7) is regarded as an important pathogenetic factor that contributes to chronic neuroinflammation. … Continue reading
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Tagged Neuroinflammation, pro-inflammatory cytokines, viral load, viruses
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Reduced pro-inflammatory cytokines in the CSF of CFS/ME
Research abstract Objectives: Previous research has provided evidence for a dysregulation in cytokine levels in the periphery of patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To date few studies have examined cytokines in the cerebrospinal fluid. The purpose of this … Continue reading
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Tagged cerebrospinal fluid, cytokines, pro-inflammatory cytokines, Sonya Marshall-Gradisnik
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Cytokines and CFS
Abstract A major hypothesis for the cause of chronic fatigue syndrome (CFS) is immune dysregulation, thought to reflect upregulated pro-inflammatory cytokines leading to the symptoms characteristic of this illness. Because symptoms worsen with physical exertion or sleep loss, we hypothesized … Continue reading
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Tagged immune dysregulation, PBLs, peripheral blood lymphocytes, pro-inflammatory cytokines
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