There is a need for broad spectrum assays and kits which make it possible to detect  in a simple way and at an early stage whether a patient suffers from a Th1- or a Th2- mediated disease. A Belgian study describes the development of an easy-to-perform self-test principle that uses a redox-active colorimetric substrate producing a clearly visible change of colour upon reaction with metabolites  present at high concentration in the urine of Th2-shifted individuals.

It also allows patients to evaluate their Th1/Th2 balance repeatedly over short periods of time to follow-up the effects of taking pre- and probiotics, neutraceuticals, drugs or any other therapeutic strategy to balance Th1/Th2 status.

The researchers used the test to confirm that CFS/ME is a Th2-mediated illness.

Self-test monitoring of the Th1/Th2 balance in health and disease with special emphasis on CFS/ME

NB  T helper cells (Th cells) are a sub-group of lymphocytes which play an important role in establishing and maximising the capabilities of  the immune system.