Tag Archives: Natural Killer cells

Potential diagnostic biomarkers in Natural Killer cells of patients with CFS/ ME

Posted on 03/16/2016 by wames

Research abstract: BACKGROUND: Chronic Fatigue Syndrome (CFS/ME) is a complex multisystem disease of unknown aetiology which causes debilitating symptoms in up to 1% of the global population. Although a large cohort of genes have been shown to exhibit altered expression … Continue reading →

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Low NK cell activity differs in ME/CFS & MS

Posted on 09/22/2015 by wames

Research abstract: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Multiple Sclerosis (MS) patients suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue related symptoms suffered by CFS/ME and MS patients, dysfunction of the immune system … Continue reading →

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Low NK Cell activity in CFS and is related to severity

Posted on 09/21/2015 by wames

Review abstract: Background: Natural killer (NK) cells act as an immune surveillance against invading pathogens and tumors. NK cell cytotoxicity (NKCC) has been reported to be decreased in patients with CFS. Methods: The objective of this review was to conduct … Continue reading →

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Immune dysfunction differs in moderate and severe CFS/ME over time

Posted on 09/21/2015 by wames

Research abstract: Background: Research has identified immunological abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), a heterogeneous illness with an unknown cause and absence of diagnostic test. There have been no CFS/ME studies examining innate and adaptive immune cells longitudinally in … Continue reading →

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Natural killer cytotoxicity in CFS

Posted on 06/15/2015 by wames

 Research abstract: Natural killer (NK) cytotoxicity of chronic fatigue syndrome (CFS) patients is decreased, as reported by several laboratories. This observation led us to query whether the NK cells also lack antibody-dependent cell-mediated cytotoxicity (ADCC). NK cells have the IgG … Continue reading →

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Dysfunction found in innate and adaptive immune systems in CFS/ME

Posted on 06/10/2015 by wames

Research abstract: Background: Abnormal immune function is often an underlying component of illness pathophysiology and symptom presentation. Functional and phenotypic immune-related alterations may play a role in the obscure pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The objective of this … Continue reading →

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Characterisation of impaired NK cells in CFS/ME

Posted on 07/17/2014 by wames

Abstract OBJECTIVE Natural Killer (NK) cells are classified into different phenotypes according to the expression of the surface markers CD56 and CD16. Each NK cell phenotype has a role in the immune response through cytotoxic activity or cytokine production. Reduced … Continue reading →

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Natural killer cells in severe CFS

Posted on 05/31/2014 by wames

Abstract Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate and adaptive immune cells that are required to sustain immunity. The presence … Continue reading →

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Review of the role of T cells in the ME/CFS immune system

Posted on 04/24/2014 by wames

Abstract Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a multifactorial disorder defined by symptom-specific criteria and characterised by severe and prolonged fatigue. CFS/ME typically affects a variety of bodily systems, including the immune system. Patients with CFS/ME exhibit significantly reduced Natural … Continue reading →

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