Tag Archives: neuropathic pain
An investigation into the modulation of T cell phenotypes by amitriptyline & nortriptyline
An investigation into the modulation of T cell phenotypes by amitriptyline and nortriptyline, by JonathanRoyds, Melissa J Conroy, Margaret R Dunne, Connail McCrory, Joanne Lysaght in European Neuropsychopharmacology, Dec 2019[doi.org/10.1016/j.euroneuro.2019.12.106] Research abstract: Amitriptyline is prescribed for treating the symptoms … Continue reading
Understanding autoantibody-mediated pain offers hope for CFS pain
Review abstract: As autoantibodies bind to target tissues, Fc-region dependent inflammation can induce pain via mediators exciting nociceptors. But recently another possibility has emerged, where autoantibody binding to nociceptors can directly cause pain, without inflammation. This is thought to occur … Continue reading
Neuropathic pain treatments
Opinion statement abstract: Neuropathic pain is notoriously variable in its severity and impact on patients, as well as in its response to treatment. Certain therapies for neuropathic pain have better evidence for their use; however, it is apparent that although … Continue reading
Amitriptyline helpful for neuropathic pain for some adults
Review abstract: BACKGROUND: This is an updated version of the original Cochrane review published in Issue 12, 2012. That review considered both fibromyalgia and neuropathic pain, but the effects of amitriptyline for fibromyalgia are now dealt with in a separate … Continue reading
Calls for use of immunotherapy to treat chronic pain
Cort Johnson writes: We all know the medical profession is poor at providing pain relief in general, but its record with regards to neuropathic or nerve pain is something else indeed. Despite the fairly large array of drugs physicians use … Continue reading
Low dose vaporised cannabis improves neuropathic pain
Research abstract We conducted a double-blind, placebo-controlled, crossover study evaluating the analgesic efficacy of vaporized cannabis in subjects, the majority of whom were experiencing neuropathic pain despite traditional treatment. Thirty-nine patients with central and peripheral neuropathic pain underwent a standardized … Continue reading
NPD1 – potential drug for nerve pain in CFS
Abstract Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury-induced mechanical allodynia and … Continue reading
Cytokines and neuropathic pain
Abstract Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in the central and peripheral nervous systems … Continue reading
