Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with\/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood.<\/p>\n
Here, we performed comprehensive metabolomic analyses <\/a>of 133 plasma<\/a> samples obtained from CFS patients and healthy controls to establish an objective diagnosis of CFS. CFS patients exhibited significant differences in intermediate metabolite concentrations in the tricarboxylic acid <\/a>(TCA) and urea cycles<\/a>.<\/p>\n The combination of ornithine\/citrulline and pyruvate\/isocitrate ratios discriminated CFS patients from healthy controls, yielding area under the receiver operating characteristic curve values of 0.801 (95% confidential interval [CI]: 0.711\u20130.890,\u00a0P\u2009<\u20090.0001) and 0.750 (95% CI: 0.584\u20130.916,\u00a0P\u2009=\u20090.0069) for training (n\u2009=\u200993) and validation (n\u2009=\u200940) datasets, respectively. These findings provide compelling evidence that a clinical diagnostic tool could be developed for CFS based on the ratios of metabolites in plasma.<\/p>\n Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles<\/a>, by Emi Yamano,\u00a0Masahiro Sugimoto,\u00a0Akiyoshi Hirayama,\u00a0Satoshi Kume ,\u00a0Masanori Yamato,\u00a0Guanghua Jin,\u00a0Seiki Tajima,\u00a0Nobuhito Goda,\u00a0Kazuhiro Iwai,\u00a0Sanae Fukuda,\u00a0Kouzi Yamaguti,\u00a0Hirohiko Kuratsune, Tomoyoshi Soga,\u00a0Yasuyoshi Watanabe &\u00a0Yosky Kataoka in<\/span> <\/p>\n","protected":false},"excerpt":{"rendered":" Research abstract: Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with\/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensive … Continue reading
\nScientific Reports<\/em>\u00a06, Article\u00a0number:\u00a034990 (2016) [Published online: 11 October 2016]<\/p>\n