{"id":11152,"date":"2016-12-14T08:47:52","date_gmt":"2016-12-14T08:47:52","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=11152"},"modified":"2016-12-14T08:47:52","modified_gmt":"2016-12-14T08:47:52","slug":"microbial-fermentation-in-the-gut-may-affect-energy-metabolism-in-mecfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/microbial-fermentation-in-the-gut-may-affect-energy-metabolism-in-mecfs\/","title":{"rendered":"Microbial fermentation in the gut may affect energy metabolism in ME\/CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Introduction:<\/strong> The human gut microbiota<\/a> has the ability to modulate host metabolism<\/a>. Metabolic profiling of the microbiota and the host biofluids may determine associations significant of a host\u2013microbe relationship.<\/p>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a long-term disorder of fatigue that is poorly understood, but has been linked to gut problems and altered microbiota.<\/p>\n

Objectives:<\/strong> Find changes in fecal microbiota and metabolites<\/a> in ME\/CFS and determine their association with blood serum and urine metabolites.<\/p>\n

Methods<\/strong>: A workflow was developed that correlates microbial counts with fecal, blood serum and urine metabolites quantitated by high-throughput 1H NMR spectroscopy. The study consists of thirty-four females with ME\/CFS (34.9\u2009\u00b1\u20091.8 SE years old) and twenty-five non-ME\/CFS female (33.0\u2009\u00b1\u20091.6 SE years old).<\/p>\n

Results<\/strong>: The workflow was validated using the non-ME\/CFS cohort where fecal short chain fatty acids <\/a>(SCFA) were associated with serum and urine metabolites indicative of host metabolism changes enacted by SCFA. In the ME\/CFS cohort a decrease in fecal lactate and an increase in fecal butyrate, isovalerate and valerate were observed along with an increase in Clostridium spp. and a decrease in Bacteroides spp.<\/p>\n

These differences were consistent with an increase in microbial fermentation of fiber and amino acids to produce SCFA in the gut of ME\/CFS patients. Decreased fecal amino acids positively correlated with substrates of gluconeogenesis and purine synthesis in the serum of ME\/CFS patients.<\/p>\n

Conclusion<\/strong>: Increased production of SCFA by microbial fermentation in the gut of ME\/CFS patients may be associated with deleterious effects on the host energy metabolism.<\/p>\n

The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis\/chronic fatigue syndrome<\/a> by\u00a0Christopher W. Armstrong,\u00a0 Neil R. McGregor, Donald P. Lewis, Henry L. Butt, Paul R. Gooley in<\/span> Metabolomics<\/em> January 2017, 13:8 [Published online 12 December 2016]<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Introduction: The human gut microbiota has the ability to modulate host metabolism. Metabolic profiling of the microbiota and the host biofluids may determine associations significant of a host\u2013microbe relationship. Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a long-term disorder … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[538,1262,537,3354,3353],"class_list":["post-11152","post","type-post","status-publish","format-standard","hentry","category-news","tag-gut-microbes","tag-metabolomics","tag-microbiota","tag-scfa","tag-short-chain-fatty-acids"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-2TS","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=11152"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11152\/revisions"}],"predecessor-version":[{"id":11153,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11152\/revisions\/11153"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=11152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=11152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=11152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}