{"id":11293,"date":"2017-01-05T09:05:23","date_gmt":"2017-01-05T09:05:23","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=11293"},"modified":"2017-01-05T09:05:23","modified_gmt":"2017-01-05T09:05:23","slug":"metabolic-profiling-reveals-disturbances-in-fatty-acid-lipid-metabolism-in-mecfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/metabolic-profiling-reveals-disturbances-in-fatty-acid-lipid-metabolism-in-mecfs\/","title":{"rendered":"Metabolic profiling reveals disturbances in fatty acid & lipid metabolism in ME\/CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) remains a continuum spectrum disease without biomarkers or simple objective tests, and therefore relies on a diagnosis from a set of symptoms to link the assortment of brain and body disorders to ME\/CFS. Although recent studies show various affected pathways, the underlying basis of ME\/CFS has yet to be established.<\/p>\n

In this pilot study, we compare plasma metabolic signatures in a discovery cohort, 17 patients and 15 matched controls, and explore potential metabolic perturbations as the aftermath of the complex interactions between genes, transcripts and proteins.<\/p>\n

This approach to examine the complex array of symptoms and underlying foundation of ME\/CFS revealed 74 differentially accumulating metabolites, out of 361 (P<0.05), and 35 significantly altered after statistical correction (Q<0.15). The latter list includes several essential energy-related compounds which could theoretically be linked to the general lack of energy observed in ME\/CFS patients.<\/p>\n

Pathway analysis points to a few pathways with high impact and therefore potential disturbances in patients, mainly taurine<\/a> metabolism and glycerophospholipid<\/a> metabolism, combined with primary bile acid<\/a> metabolism, as well as glyoxylate and dicarboxylate metabolism and a few other pathways, all involved broadly in fatty acid metabolism<\/a>.<\/p>\n

Purines<\/a>, including ADP and ATP, pyrimidines and several amino acid metabolic pathways were found to be significantly disturbed. Finally, glucose and oxaloacetate were two main metabolites<\/a> affected that have a major effect on sugar and energy levels. Our work provides a prospective path for diagnosis and understanding of underlying mechanisms of ME\/CFS.<\/p>\n

Metabolic profiling of a myalgic encephalomyelitis\/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism<\/a> by Arnaud Germain, David Ruppert, Susan M Levine and Maureen R Hanson in<\/span> Mol. BioSyst<\/em>. [First published online 23 Dec 2016]<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) remains a continuum spectrum disease without biomarkers or simple objective tests, and therefore relies on a diagnosis from a set of symptoms to link the assortment of brain and body disorders to ME\/CFS. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3398,3397,2530,3396,20,308,697,2823],"class_list":["post-11293","post","type-post","status-publish","format-standard","hentry","category-news","tag-arnaud-germain","tag-david-ruppert","tag-dr-susan-levine","tag-fatty-acid-metabolism","tag-fatty-acids","tag-lipid-profile","tag-metabolic-profiling","tag-prof-maureen-hanson"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-2W9","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=11293"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11293\/revisions"}],"predecessor-version":[{"id":11326,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11293\/revisions\/11326"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=11293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=11293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=11293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}