{"id":11464,"date":"2017-01-18T10:45:15","date_gmt":"2017-01-18T10:45:15","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=11464"},"modified":"2017-01-18T10:45:15","modified_gmt":"2017-01-18T10:45:15","slug":"a-systematic-review-of-the-association-between-fatigue-genetic-polymorphisms","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/a-systematic-review-of-the-association-between-fatigue-genetic-polymorphisms\/","title":{"rendered":"A systematic review of the association between fatigue &#038; genetic polymorphisms"},"content":{"rendered":"<h3><strong>Review abstract:<\/strong><\/h3>\n<p>Fatigue is one of the most common and distressing symptoms, leading to markedly decreased quality of life among a large subset of patients with a variety of disorders. Susceptibility to fatigue may be influenced by genetic factors including <a href=\"https:\/\/ghr.nlm.nih.gov\/primer\/genomicresearch\/snp\" target=\"_blank\">single nucleotide polymorphisms<\/a> (SNPs), especially in the regulatory regions, of relevant genes.<\/p>\n<p>To further investigate the association of SNPs with fatigue in various patient populations, a systematic search was conducted on Pubmed, CINAHL, PsycINFO, and Sociological Abstracts Database for fatigue related-terms in combination with polymorphisms or genetic variation-related terms.<\/p>\n<p>Fifty papers in total met the inclusion and exclusion criteria for this analysis. These 50 papers were further classified into three subgroups for evaluation: chronic fatigue syndrome (CFS), cancer-related fatigue (CRF) and other disease-related fatigue.<\/p>\n<p>SNPs in regulatory pathways of immune and neurotransmitter systems were found to play important roles in the etiologies of CFS, CRF and other disease-related fatigue. Evidence for associations between elevated fatigue and specific polymorphisms in TNF\u03b1, IL1b, IL4 and IL6 genes was revealed for all three subgroups of fatigue.<\/p>\n<p>We also found CFS shared a series of polymorphisms in HLA, IFN-\u03b3, 5-HT and NR3C1 genes with other disease-related fatigue, however these SNPs (excluding IFN-\u03b3) were not found to be adequately investigated in CRF. Gaps in knowledge related to fatigue etiology and recommendations for future research are further discussed.<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28089639\" target=\"_blank\">A systematic review of the association between fatigue and genetic polymorphisms<\/a>, by Wang T, Yin J, Miller AH, Xiao C <strong>in<\/strong> <em>Brain Behav Immun.<\/em> 2017 Jan 12 pii\u00a0[Epub ahead of print]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Review abstract: Fatigue is one of the most common and distressing symptoms, leading to markedly decreased quality of life among a large subset of patients with a variety of disorders. Susceptibility to fatigue may be influenced by genetic factors including &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/a-systematic-review-of-the-association-between-fatigue-genetic-polymorphisms\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1025,3443,9,18,1741,1186,3444],"class_list":["post-11464","post","type-post","status-publish","format-standard","hentry","category-news","tag-andrew-h-miller","tag-cancer-related-fatigue","tag-chronic-fatigue","tag-gene-expression","tag-single-nucleotide-polymorphisms","tag-snps","tag-t-wang"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-2YU","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=11464"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11464\/revisions"}],"predecessor-version":[{"id":11473,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11464\/revisions\/11473"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=11464"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=11464"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=11464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}