{"id":11526,"date":"2017-01-23T07:27:10","date_gmt":"2017-01-23T07:27:10","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=11526"},"modified":"2017-01-23T07:27:10","modified_gmt":"2017-01-23T07:27:10","slug":"natural-course-of-chronic-disabling-fatigue-in-adolescents","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/natural-course-of-chronic-disabling-fatigue-in-adolescents\/","title":{"rendered":"Natural course of chronic disabling fatigue in adolescents"},"content":{"rendered":"

Research abstract<\/strong><\/h3>\n

Objective:\u00a0\u00a0 <\/strong>Little is known about persistence of or recovery from chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) in adolescents. Previous studies have small sample sizes, short follow-up or have focused on fatigue rather than CFS\/ME or, equivalently, chronic fatigue, which is disabling. This work aimed to describe the epidemiology and natural course of CFS\/ME in adolescents aged 13\u201318 years.<\/p>\n

Design:\u00a0\u00a0 <\/strong>Longitudinal follow-up of adolescents enrolled in the Avon Longitudinal Study of Parents and Children.<\/p>\n

Setting:<\/strong>\u00a0 Avon, UK.<\/p>\n

Participants:<\/strong>\u00a0 \u00a0We identified adolescents who had disabling fatigue of >6 months duration without a known cause at ages 13, 16 and 18\u2005years. We use the term \u2018chronic disabling fatigue\u2019 (CDF) because CFS\/ME was not verified by clinical diagnosis. We used multiple imputation to obtain unbiased estimates of prevalence and persistence.<\/p>\n

Results:\u00a0 <\/strong>\u00a0The estimated prevalence of CDF was 1.47% (95% CI 1.05% to 1.89%) at age 13, 2.22% (1.67% to 2.78%) at age 16 and 2.99% (2.24% to 3.75%) at age 18. Among adolescents with CDF of 6\u2005months duration at 13\u2005years 75.3% (64.0% to 86.6%) were not classified as such at age 16.<\/p>\n

Similar change was observed between 16 and 18\u2005years (75.0% (62.8% to 87.2%)). Of those with CDF at age 13, 8.02% (0.61% to 15.4%) presented with CDF throughout the duration of adolescence.<\/p>\n

Conclusions:<\/strong> \u00a0The prevalence of CDF lasting 6\u2005months or longer (a proxy for clinically diagnosed CFS\/ME) increases from 13 to 18\u2005years. However, persistent CDF is rare in adolescents, with approximately 75% recovering after 2\u20133\u2005years.<\/p>\n

What is already known on this topic?<\/strong><\/p>\n

Chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) is relatively common and disabling in children and adolescents. Previous studies (typically with small samples) have reported inconsistent estimates of persistence of CFS\/ME during adolescence. The long-term prognosis of the condition in those not receiving treatment is not known.<\/p>\n

What this study adds?<\/strong><\/p>\n

The prevalence of chronic disabling fatigue (CDF), a proxy for clinically diagnosed CFS\/ME, increases during adolescence.<\/p>\n

Approximately 25% persist over a 2\u20133-year follow-up. Only 8% of children with CDF at age 13 had CDF at 16 and 18\u2005years.<\/p>\n

Natural course of chronic fatigue syndrome\/myalgic encephalomyelitis in adolescents<\/a>, by Tom Norris, Simon M Collin, Kate Tilling, Roberto Nuevo, Stephen A Stansfeld, Jonathan AC Sterne, Jon Heron, Esther Crawley in<\/span> Arch Dis Child<\/em> [Published Online\u00a019 January 2017]<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract Objective:\u00a0\u00a0 Little is known about persistence of or recovery from chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) in adolescents. Previous studies have small sample sizes, short follow-up or have focused on fatigue rather than CFS\/ME or, equivalently, chronic fatigue, which … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[625,2372,9,416,2371,427,3292],"class_list":["post-11526","post","type-post","status-publish","format-standard","hentry","category-news","tag-adolescents","tag-avon-longitudinal-study-of-parents-and-children","tag-chronic-fatigue","tag-dr-esther-crawley","tag-simon-m-collin","tag-teenagers","tag-tom-norris"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-2ZU","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=11526"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11526\/revisions"}],"predecessor-version":[{"id":11541,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11526\/revisions\/11541"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=11526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=11526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=11526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}