{"id":11641,"date":"2017-01-27T09:13:00","date_gmt":"2017-01-27T09:13:00","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=11641"},"modified":"2017-01-27T09:13:00","modified_gmt":"2017-01-27T09:13:00","slug":"the-search-for-a-non-invasive-diagnostic-test-for-mecfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/the-search-for-a-non-invasive-diagnostic-test-for-mecfs\/","title":{"rendered":"The search for a non invasive diagnostic test for ME\/CFS"},"content":{"rendered":"<p><strong>Solve ME\/CFS Initiative<\/strong>\u00a0blog post, 13 January 2013: <a href=\"http:\/\/solvecfs.org\/promising-non-invasive-diagnostic-testing-project-seeks-to-detect-mecfs\/\" target=\"_blank\">Non-Invasive Diagnostic Test Project Seeks to Detect ME\/CFS<\/a><\/p>\n<p>This week, we highlight the Cathleen J. Gleeson PhD Fund and our collaborative partnership with the University of Washington on diagnostic testing in ME\/CFS.<\/p>\n<p>This study of diagnostics and metabolic imaging uses advanced, non-invasive magnetic resonance spectroscopy (MRS) to measure muscle metabolites in ME\/CFS patients before and after fatiguing exercise.<\/p>\n<p>Pilot testing conducted earlier through this project compared a single patient with ME\/CFS to that of a matched healthy control. Preliminary analysis revealed abnormal levels of certain metabolites, most notably NAD (P) H, in the ME\/CFS subject compared to the healthy control. This result points to cellular metabolic dysfunction in a specific pathway that may itself promote and suffer from oxidative stress. The difference in metabolic profile was most pronounced the day following fatiguing exercise, mirroring a commonly reported timeline of symptoms for those with ME\/CFS.<\/p>\n<p>This preliminary data suggests that an abnormal response of NADP and its cofactor, NAD(P)H, may be a molecular marker for ME\/CFS-related oxidative stress at the cellular level.<\/p>\n<p>The proposed experiments are designed to test whether this abnormality is also observed in a larger set of subjects diagnosed with ME\/CFS. Confirmation of the result would establish MRS as a powerful tool to non-invasively detect and measure a molecular signature of this disease. If successful, our research would establish a new, breakthrough research platform for understanding the molecular basis of ME\/CFS.<\/p>\n<p>This study is made possible by a grant from the Cathleen J. Gleeson PhD Fund and is led by Kevin Conley, PhD, professor of radiology and co-director of the Translational Center for Metabolic Imaging at the University of Washington and David Maughan, PhD, a professor emeritus of molecular physiology &amp; biophysics at the University of Vermont and visiting scholar in radiology at the University of Washington.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Solve ME\/CFS Initiative\u00a0blog post, 13 January 2013: Non-Invasive Diagnostic Test Project Seeks to Detect ME\/CFS This week, we highlight the Cathleen J. Gleeson PhD Fund and our collaborative partnership with the University of Washington on diagnostic testing in ME\/CFS. This &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/the-search-for-a-non-invasive-diagnostic-test-for-mecfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[2304,715,3475,3476,1053,1007],"class_list":["post-11641","post","type-post","status-publish","format-standard","hentry","category-news","tag-david-maughan","tag-diagnostic-test","tag-kevin-conley","tag-magnetic-resonance-spectroscopy","tag-post-exertional-deterioration","tag-solve-mecfs-initiative"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-31L","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11641","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=11641"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11641\/revisions"}],"predecessor-version":[{"id":11654,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11641\/revisions\/11654"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=11641"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=11641"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=11641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}