{"id":11685,"date":"2017-01-31T09:14:29","date_gmt":"2017-01-31T09:14:29","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=11685"},"modified":"2017-01-31T09:14:29","modified_gmt":"2017-01-31T09:14:29","slug":"giardia-specific-cellular-immune-responses-in-post-giardiasis-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/giardia-specific-cellular-immune-responses-in-post-giardiasis-cfs\/","title":{"rendered":"Giardia-specific cellular immune responses in post-giardiasis CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Background<\/strong>: The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform.<\/p>\n

The aim of this study was to evaluate specific anti-Giardia cellular immunity in cases that developed CFS after Giardia infection<\/a> compared to cases that recovered well. Patients reporting chronic fatigue in a questionnaire study three years after a Giardia outbreak were clinically evaluated five years after the outbreak and grouped according to Fukuda criteria for CFS and idiopathic chronic fatigue.<\/p>\n

Giardia specific immune responses were evaluated in 39 of these patients by proliferation assay, T cell activation and cytokine release analysis. 20 Giardia exposed non-fatigued individuals and 10 healthy unexposed individuals were recruited as controls.<\/p>\n

Results:<\/strong> Patients were clinically classified into CFS (n\u2009=\u200915), idiopathic chronic fatigue (n\u2009=\u20095), fatigue from other causes (n\u2009=\u20099) and recovered from fatigue (n\u2009=\u200910). There were statistically significant antigen specific differences between these Giardia exposed groups and unexposed controls.<\/p>\n

However, we did not find differences between the Giardia exposed fatigue classification groups with regard to CD4 T cell activation, proliferation or cytokine levels in 6 days cultured PBMCs. Interestingly, sCD40L<\/a> was increased in patients with PI-CFS and other persons with fatigue after Giardia infection compared to the non-fatigued group, and correlated well with fatigue levels at the time of sampling.<\/p>\n

Conclusion:<\/strong> Our data show antigen specific cellular immune responses in the groups previously exposed to Giardia and increased sCD40L in fatigued patients.<\/p>\n

Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome<\/a>, by Kurt Hanevik, Einar Kristoffersen, Kristine M\u00f8rch, Kristin Paulsen Rye, Steinar S\u00f8rnes, Staffan Sv\u00e4rd, \u00d8ystein Bruserud and Nina Langeland in<\/span> BMC Immunology<\/em> 2017 18:5 [Published: 28 January 2017]<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Background: The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform. The aim of this study was to … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1084,698],"class_list":["post-11685","post","type-post","status-publish","format-standard","hentry","category-news","tag-giardia-infection","tag-immune-system-dysfunction"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-32t","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=11685"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11685\/revisions"}],"predecessor-version":[{"id":11690,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11685\/revisions\/11690"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=11685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=11685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=11685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}