{"id":11884,"date":"2017-02-17T08:37:26","date_gmt":"2017-02-17T08:37:26","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=11884"},"modified":"2017-02-17T08:37:26","modified_gmt":"2017-02-17T08:37:26","slug":"inflammation-test-could-be-tailor-made-for-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/inflammation-test-could-be-tailor-made-for-cfs\/","title":{"rendered":"Inflammation test could be tailor-made for CFS"},"content":{"rendered":"

Simmaron research<\/strong> blog post, by Cort Johnson, 12 February 2017: Inflammation Test Could be Tailor-Made for Chronic Fatigue Syndrome: Are the Mitochondria To Blame?<\/a><\/p>\n

\u201cMore than 90 percent of all noncommunicable diseases of aging are associated with chronic inflammation\u201d \u00a0David Furman \u00a0\u2013 Stanford Institute for Immunity, Transplantation and Infection<\/a><\/p>\n

Inflammation is a big deal in the medical world. \u00a0Even mild inflammation, if it\u2019s consistently present, is known to increase one\u2019s risk of getting cardiovascular diseases, diabetes, Alzheimer\u2019s and\u00a0many others. Standard tests for inflammation such as C-reactive protein or cholesterol, however, are often unrevealing. For instance, inflammation is a key driver of heart disease, but the first sign for many of heart problems is still a heart attack.<\/p>\n

Chronic, low levels of inflammation are found in many serious diseases.\u00a0 Likewise it\u2019s been said that chronic fatigue syndrome (ME\/CFS) and fibromyalgia (FM) are inflammatory diseases, but standard tests for inflammation often indicate that none is present. Dr. Montoya believes that current inflammation tests are missing a lot and that future tests will be able to detect the kind of inflammation occurring in ME\/CFS.<\/p>\n

Given that tests for inflammation are relatively crude, it makes sense that significant efforts would be directed to developing a better test.\u00a0 It\u2019s no surprise that Mark Davis at Stanford is involved.<\/p>\n

Davis\u2019s\u00a0Institute for Immunity, Transplantation and Infection\u00a0is spitting out interesting findings like there\u2019s no tomorrow. \u00a0Coffee drinkers and dark chocolate lovers were recently pleased to learn that metabolites associated with caffeine and dark chocolate were associated with increased longevity and reduced inflammation<\/a>. In fact, incubating cells with these metabolites \u00a0shut off their inflammatory response.<\/p>\n

A 2015 study overturned decades of perceived wisdom that self-attacking or auto-reactive lymphocytes are mostly weeded out early in childhood. (They\u2019re actually very common in adults.)\u00a0 Davis upended another pillar of orthodoxy when he determined that environment \u2013 the microbes, toxins, foods, etc. that we encounter \u2013 have far more of an impact on our immune system than our genes. Davis found, for instance, that a single cytomegalovirus infection <\/a>causes stunningly large and permanent changes to our immune systems.<\/p>\n

Davis is bold enough to want to replace all mouse research forever (\u201cFree the mice!\u201d) with a human based approach using immune modeling. In 2015 the Bill Gates foundation gave him $50 million to figure out how to build more effective vaccines<\/a>. Lastly and most importantly for us, Davis is one of the luminaries sitting on the Open Medicine Foundation\u2019s Scientific Board.<\/a> \u00a0A friend of Ron Davis, I met him at the Davis\u2019 Palo Alto fundraiser a year or so ago. (He said when Ron Davis asks you to do something, you do it).<\/p>\n

Davis may have come up with the best test yet for inflammation \u2013 an apt subject for ME\/CFS and FM patients.\u00a0 In fact this test sounds like it was made for people with chronic fatigue syndrome and fibromyalgia.<\/p>\n

Old Before Their Time?<\/strong>
\nThe study originated in an attempt to quantify the link between inflammation and something perhaps pertinent to chronic fatigue syndrome and fibromyalgia \u2013 aging.\u00a0 While the evidence is sketchy, it does suggest that people with ME\/CFS and\/or FM might be aging faster.\u00a0 Decreased brain gray matter<\/a>, shortened telomere lengths,<\/a> \u00a0gait alterations<\/a>, and the cognitive and sleep issues<\/a>, could all reflect a group of patients who are aging a bit before their time.<\/p>\n

The Study<\/strong>
\nScientists develop inflammation test that may predict cardiovascular disease<\/a>\u00a0Cell Syst.\u00a02016 Oct 26;3(4):374-384.e4. doi: 10.1016\/j.cels.2016.09.009. Epub 2016 Oct 13.\u00a0Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans.\u00a0Shen-Orr SS1,\u00a0Furman D2,\u00a0Kidd BA2,\u00a0Hadad F3,\u00a0Lovelace P4,\u00a0Huang YW4, et. al.<\/p>\n

Read more about the study<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Simmaron research blog post, by Cort Johnson, 12 February 2017: Inflammation Test Could be Tailor-Made for Chronic Fatigue Syndrome: Are the Mitochondria To Blame? \u201cMore than 90 percent of all noncommunicable diseases of aging are associated with chronic inflammation\u201d \u00a0David … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[337],"class_list":["post-11884","post","type-post","status-publish","format-standard","hentry","category-news","tag-chronic-inflammation"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-35G","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=11884"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11884\/revisions"}],"predecessor-version":[{"id":11926,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11884\/revisions\/11926"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=11884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=11884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=11884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}