{"id":11984,"date":"2017-02-27T08:42:46","date_gmt":"2017-02-27T08:42:46","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=11984"},"modified":"2017-02-27T08:42:46","modified_gmt":"2017-02-27T08:42:46","slug":"neuro-inflammatory-etiopathology-of-mecfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/neuro-inflammatory-etiopathology-of-mecfs\/","title":{"rendered":"Neuro inflammatory etiopathology of ME\/CFS"},"content":{"rendered":"<p><strong>Article abstract:<\/strong><\/p>\n<p>Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a debilitating multi-systemic chronic illness of unknown etiology, classified as a neurological disorder by the World Health Organization (WHO).<\/p>\n<p>The symptomatology of the condition appears to emanate from a variety of sources of chronic neurological disturbance and associated distortions, and chronicity, in noxious sensory signaling and neuroimmune activation.<\/p>\n<p>This article incorporates a summary review and discussion of biomedical research considered relevant to this essential conception perspective. It is intended to provide stakeholders with a concise, integrated outline disease model in order to help demystify this major public health problem.<\/p>\n<p>The primary etiopathological factors presented are:<\/p>\n<ul>\n<li>(A) Postural\/biomechanical pain signaling, affecting adverse neuroexcitation, in the context of compression, constriction, strain, or damage of vertebral-regional bone and neuromuscular tissues;<\/li>\n<li>(B) Immune mediated inflammatory sequelae, in the context of prolonged immunotropic neurotrophic infection\u2014with lymphotropic\/gliotropic\/glio-toxic varieties implicated in particular;<\/li>\n<li>(C) A combination of factors A and B. Sustained glial activation under such conditions is associated with oxidative and nitrosative stress, neuroinflammation, and neural sensitivity.<\/li>\n<\/ul>\n<p>These processes collectively enhance the potential for multi-systemic disarray involving endocrine pathway aberration, immune and mitochondrial dysfunction, and neurodegeneration, and tend toward still more intractable synergistic neuro-glial dysfunction (gliopathy), autoimmunity, and central neuronal sensitization.<\/p>\n<p><a href=\"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2017.00088\/full\" target=\"_blank\">The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS), <\/a>by Independent Health Researcher and Consultant, Julian AG Glassford, from Shrewsbury <span style=\"text-decoration: underline;\">in <\/span><em>Front. Physiol.,<\/em> 17 February 2017<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Article abstract: Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a debilitating multi-systemic chronic illness of unknown etiology, classified as a neurological disorder by the World Health Organization (WHO). The symptomatology of the condition appears to emanate from a variety of sources &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/neuro-inflammatory-etiopathology-of-mecfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3531,3530,705],"class_list":["post-11984","post","type-post","status-publish","format-standard","hentry","category-news","tag-etiopathology","tag-julian-ag-glassford","tag-neuroinflammation"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-37i","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=11984"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11984\/revisions"}],"predecessor-version":[{"id":11989,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/11984\/revisions\/11989"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=11984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=11984"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=11984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}