{"id":12335,"date":"2017-03-23T08:22:31","date_gmt":"2017-03-23T08:22:31","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=12335"},"modified":"2017-03-23T08:22:31","modified_gmt":"2017-03-23T08:22:31","slug":"pace-trial-claims-of-recovery-are-not-justified-by-the-data-a-rejoinder-to-sharpe-chalder-johnson-goldsmith-white","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/pace-trial-claims-of-recovery-are-not-justified-by-the-data-a-rejoinder-to-sharpe-chalder-johnson-goldsmith-white\/","title":{"rendered":"PACE trial claims of recovery are not justified by the data: a rejoinder to Sharpe, Chalder, Johnson, Goldsmith & White"},"content":{"rendered":"

Following a response from the PACE trial researchers<\/a> to their re-analysis from the\u00a0PACE trial researchers Wilshire\u00a0et al have published\u00a0a reply:<\/h3>\n

Article abstract:\u00a0<\/strong><\/p>\n

BACKGROUND:<\/strong> Recently, we critically evaluated the claim from the PACE trial <\/a>that cognitive behavioural therapy (CBT) and graded exercise therapy (GET) can lead to recovery from chronic fatigue syndrome.<\/p>\n

We showed that the trial\u2019s definition of recovery was so loose it failed to capture the term\u2019s core meaning. Also, this definition was substantially loosened very late in the trial, in ways that favoured the study hypotheses. The investigators do not acknowledge any of these criticisms and stand by their original analyses.<\/p>\n

PURPOSE<\/strong>: To examine the arguments advanced in defence of PACE\u2019s recovery claims.<\/p>\n

METHODS<\/strong>: Drawing on various sources of evidence, we consider three major arguments raised in defence of PACE\u2019s recovery claims: 1) that since there is no agreed definition of recovery, it comes down to a matter of opinion; 2) that the original definition was \u201ctoo stringent\u201d; and 3) the revised definition generates results that align with previous studies.<\/p>\n

RESULTS:<\/strong> We find that: 1) \u201crecovery\u201d is a strong claim, which implies evidence a return to health, and that the trial\u2019s final definition did not preserve this core meaning; 2) there is no evidence to suggest that the original protocol-specified definition was \u201ctoo stringent\u201d; 3) absolute recovery rates from other\u00a0studies are not a legitimate source of support for the recovery definition used.<\/p>\n

CONCLUSIONS:<\/strong> The PACE trial provides no evidence that CBT and GET can lead to recovery from CFS. The recovery claims made in the PACE trial are therefore misleading for patients and clinicians.<\/p>\n

PACE trial claims of recovery are not justified by the data: A Rejoinder to Sharpe, Chalder, Johnson, Goldsmith and White<\/a>, by\u00a0Carolyn Wilshire Tom Kindlon and Simon McGrath,\u00a0 [Published: 22 March 2017] Full text available on open access<\/p>\n","protected":false},"excerpt":{"rendered":"

Following a response from the PACE trial researchers to their re-analysis from the\u00a0PACE trial researchers Wilshire\u00a0et al have published\u00a0a reply: Article abstract:\u00a0 BACKGROUND: Recently, we critically evaluated the claim from the PACE trial that cognitive behavioural therapy (CBT) and graded … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[2233,11,426,10,481,310,743,543,1495],"class_list":["post-12335","post","type-post","status-publish","format-standard","hentry","category-news","tag-carolyn-e-wilshire","tag-cbt","tag-cognitive-behavioural-therapy","tag-get","tag-graded-exercise-therapy","tag-pace-trial","tag-recovery","tag-simon-mcgrath","tag-tom-kindlon"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3cX","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=12335"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12335\/revisions"}],"predecessor-version":[{"id":12336,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12335\/revisions\/12336"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=12335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=12335"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=12335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}