{"id":12351,"date":"2017-02-28T09:02:13","date_gmt":"2017-02-28T09:02:13","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=12351"},"modified":"2017-03-31T09:02:52","modified_gmt":"2017-03-31T09:02:52","slug":"effectiveness-of-long-term-doxycycline-treatment-cbt-on-fatigue-severity-in-patients-with-q-fever-fatigue-syndrome","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/effectiveness-of-long-term-doxycycline-treatment-cbt-on-fatigue-severity-in-patients-with-q-fever-fatigue-syndrome\/","title":{"rendered":"Effectiveness of long-term Doxycycline treatment & CBT on fatigue severity in patients with Q Fever Fatigue Syndrome"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Background:<\/strong> Approximately 20% of patients with acute Q fever will develop chronic fatigue, referred to as Q fever fatigue syndrome<\/a> (QFS). The objective of this randomized controlled clinical trial was to assess the efficacy of either long-term treatment with doxycycline or cognitive-behavioral therapy (CBT) in reducing fatigue severity in patients with QFS.<\/p>\n

Methods:<\/strong> Adult patients were included who met the QFS criteria according to the Dutch guideline: a new onset of severe fatigue lasting \u22656 months with significant disabilities, related to an acute Q fever infection, without other somatic or psychiatric comorbidity explaining the fatigue. Using block randomization, patients were randomized between oral study medication and CBT (2:1) for 24 weeks.<\/p>\n

Second, a double-blind randomization between doxycycline (200 mg\/day, once daily) and placebo was performed in the medication group. Primary outcome was fatigue severity at end of treatment (EOT; week 26), assessed with the Checklist Individual Strength subscale Fatigue Severity.<\/p>\n

Results:<\/strong> Of 155 patients randomized, 154 were included in the intention-to-treat analysis (doxycycline, 52; placebo, 52; CBT, 50).<\/p>\n

At EOT, fatigue severity was similar between doxycycline (40.8 [95% confidence interval {CI}, 37.3-44.3]) and placebo (37.8 [95% CI, 34.3-41.2]; difference, doxycycline vs placebo, -3.0 [97.5% CI, -8.7 to 2.6]; P = .45). Fatigue severity was significantly lower after CBT<\/p>\n

(31.6 [95% CI, 28.0-35.1]) than after placebo (difference, CBT vs placebo, 6.2 [97.5% CI, .5-11.9]; P = .03).<\/p>\n

Conclusions:<\/strong> CBT is effective in reducing fatigue severity in QFS patients. Long-term treatment with doxycycline does not reduce fatigue severity in QFS patients compared to placebo.<\/p>\n

Effectiveness of Long-term Doxycycline Treatment and Cognitive-Behavioral Therapy on Fatigue Severity in Patients with Q Fever Fatigue Syndrome (Qure Study): A Randomized Controlled Trial,<\/a> by Keijmel SP, Delsing CE, Bleijenberg G, van der Meer JW, Donders RT, Leclercq M, Kampschreur LM, van den Berg M, Sprong T, Nabuurs-Franssen MH, Knoop H, Bleeker-Rovers CP in<\/span> Clin Infect Dis.<\/em> 2017 Feb 27<\/p>\n

Note:<\/strong> protocol for the Qure study<\/a><\/p>\n

Clinical Trials Registration<\/strong>.: NCT01318356<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Background: Approximately 20% of patients with acute Q fever will develop chronic fatigue, referred to as Q fever fatigue syndrome (QFS). The objective of this randomized controlled clinical trial was to assess the efficacy of either long-term treatment … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1999,2406],"class_list":["post-12351","post","type-post","status-publish","format-standard","hentry","category-news","tag-q-fever-fatigue-syndrome","tag-qfs"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3dd","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=12351"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12351\/revisions"}],"predecessor-version":[{"id":12352,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12351\/revisions\/12352"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=12351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=12351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=12351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}