{"id":12841,"date":"2017-05-04T07:06:50","date_gmt":"2017-05-04T07:06:50","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=12841"},"modified":"2017-05-04T07:09:14","modified_gmt":"2017-05-04T07:09:14","slug":"the-role-of-cytokine-ip-10-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/the-role-of-cytokine-ip-10-in-cfs\/","title":{"rendered":"The role of cytokine IP-10 in CFS"},"content":{"rendered":"

Research Abstract:<\/strong><\/p>\n

The role of IP-10 in Chronic Fatigue Syndrome<\/a>, by\u00a0Anne McArdle, Arief Gusnanto, Kate Ear, George\u00a0Sakellariou, Clare Lawton, Daniel Owens, Graeme\u00a0Close, Michael Beadsworth, Louise Dye in<\/span> FASEB Journal<\/em>\u00a0Vol. 31:1 Supplement, lb789\u00a0 April 2017<\/p>\n

Chronic fatigue syndrome (CFS) is a severely debilitating and complex\u00a0illness of uncertain cause, characterised by prolonged, fatigue\u00a0triggered by minimal activity. There is evidence that CFS is associated\u00a0with chronic inflammation. Studies have shown that plasma levels of\u00a0cytokines<\/a> are chronically modified in patients with CFS.<\/p>\n

This study\u00a0examined physiological, subjective and cognitive factors associated with\u00a0plasma cytokine concentrations in a cohort of 92 patients compared with\u00a0age and sex matched healthy controls. A sub-group of patients and\u00a0healthy controls (HCs) also underwent more detailed analyses of muscle\u00a0function, cytokine production and cognitive function.<\/p>\n

Patients were\u00a0diagnosed with CFS if they met the Oxford criteria for Chronic Fatigue<\/a>\u00a0 Syndrome and recommended NICE guidelines<\/a>. Patients completed a number of\u00a0validated questionnaires including the Chalder Fatigue Questionnaire<\/a>\u00a0(CFQ) which is considered a valid and reliable measure of fatigue in\u00a0patients with CFS.<\/p>\n

Patients with CFS demonstrated a characteristic significant reduction in\u00a0Maximal Voluntary Contraction Force <\/a>compared with HCs. Data on plasma\u00a0concentrations of 27 pro- and anti-inflammatory cytokines were analysed\u00a0using multiple or logistic regression with age and sex which were\u00a0significant covariates included in each model.<\/p>\n

CFS was strongly\u00a0associated with a limited number of cytokines. Diagnosis of CFS was\u00a0 associated with increased plasma contents of MIP-1a, MIP-1b and RANTES\u00a0(p<0.05) and marginally with Eotaxin (p=0.07) when modelled\u00a0individually. MVC and self-reported fatigue both showed particularly\u00a0strong associations with plasma IP-10 concentrations. Muscle content of\u00a0IP-10 mRNA was significantly elevated, suggesting that, at least in\u00a0part, muscle was a source of this IP-10 but not the other cytokines.<\/p>\n

Pairwise associations between MVC and cytokines demonstrated that the\u00a0reduced MVC seen in patients with CFS was strongly associated with\u00a0plasma levels of IP-10, TNF-alpha and IL-5. Further analyses revealed\u00a0strong correlations between plasma RANTES and eotaxin levels and poorer\u00a0verbal recall and RTs of patients with CFS. The consistent association\u00a0of IP-10 with the physiological features and of RANTES and eotaxin with\u00a0the cognitive features of CFS provides compelling evidence for a role of\u00a0these cytokine\/ chemokines in the physiological and cognitive pathology\u00a0of CFS.<\/p>\n

This work was funded by the Medical Research Council.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research Abstract: The role of IP-10 in Chronic Fatigue Syndrome, by\u00a0Anne McArdle, Arief Gusnanto, Kate Ear, George\u00a0Sakellariou, Clare Lawton, Daniel Owens, Graeme\u00a0Close, Michael Beadsworth, Louise Dye in FASEB Journal\u00a0Vol. 31:1 Supplement, lb789\u00a0 April 2017 Chronic fatigue syndrome (CFS) is a … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[113,3736,1963],"class_list":["post-12841","post","type-post","status-publish","format-standard","hentry","category-news","tag-cytokines","tag-ip-10","tag-prof-anne-mcardle"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3l7","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=12841"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12841\/revisions"}],"predecessor-version":[{"id":12871,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/12841\/revisions\/12871"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=12841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=12841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=12841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}