{"id":13165,"date":"2017-06-01T18:37:33","date_gmt":"2017-06-01T18:37:33","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=13165"},"modified":"2017-06-01T18:41:42","modified_gmt":"2017-06-01T18:41:42","slug":"endogenous-pain-facilitation-rather-than-inhibition-differs-between-people-with-cfs-ms-and-controls","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/endogenous-pain-facilitation-rather-than-inhibition-differs-between-people-with-cfs-ms-and-controls\/","title":{"rendered":"Endogenous pain facilitation rather than inhibition differs between people with CFS, MS, and controls"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Endogenous pain facilitation rather than inhibition differs\u00a0between people with Chronic Fatigue Syndrome, Multiple Sclerosis,\u00a0and controls<\/a>: An observational study, by\u00a0Simon M. Collin, Jo Nijs, Mira Meeus, Andrea Polli,\u00a0Barbara Willekens, Kelly Ickmans in Pain Physician, May 2017, Volume 20, Issue 4\u00a0ppE489-E497\u00a0[Published 20 May 2017]<\/p>\n

Background:
\nCommonalities in the core symptoms of fatigue and cognitive dysfunction\u00a0experienced by chronic fatigue syndrome (CFS, also known as ME) and\u00a0multiple sclerosis (MS) patients have been described. Many CFS and MS\u00a0patients also experience chronic pain, which has been attributed to\u00a0central sensitization in both groups of patients. However, the\u00a0 characteristics of pain in CFS and MS patients have not been compared.<\/p>\n

Objectives:
\nTo compare experimental pain measurements in patients with CFS or MS and\u00a0healthy controls.<\/p>\n

Study design:
\nObservational study.<\/p>\n

Setting:
\nThis study took place in Belgium at Vrije Universiteit Brussel and the\u00a0University of Antwerp.<\/p>\n

Methods
\nPressure pain thresholds, temporal summation, conditioned pain\u00a0modulation, and occlusion cuff pressure thresholds rated as painful (1st\u00a0cuff pressure threshold) and as 3\/10 on a verbal numerical scale (2nd\u00a0cuff pressure threshold) were measured in patients with CFS (n=48), MS\u00a0(n=19) and healthy pain-free controls (n=30). Adjusted between-group\u00a0differences were estimated using linear regression models.<\/p>\n

Results
\nFinger pain pressure thresholds of patients with CFS, compared with\u00a0patients with MS, were 25% lower (difference ratio 0.75 [95% CI 0.59,\u00a00.95], P=0.02) and shoulder pain pressure thresholds were 26% lower\u00a0(difference ratio 0.74 [0.52, 1.04], P=0.08).<\/p>\n

Compared with patients\u00a0with MS, patients with CFS had 29% lower first cuff pressure threshold\u00a0(difference ratio 0.71 [0.53, 0.94], P=0.02) and 41% lower 2nd cuff\u00a0pressure threshold (0.59 [0.41, 0.86], P=0.006). Finger temporal\u00a0summation was higher in patients with CFS than in patients with MS (mean\u00a0difference 1.15 [0.33, 1.97], P=0.006), but there were no differences in\u00a0shoulder temporal summation or conditioned pain modulation at either\u00a0site.<\/p>\n

Differences between patients with CFS and MS tended to be greater\u00a0than between either patient group and healthy controls. Pain pressure\u00a0thresholds and cuff pressure thresholds tended to be positively\u00a0correlated, and temporal summation negatively correlated, with higher\u00a0physical function and lower fatigue in both groups of patients.<\/p>\n

Subjective pain in patients with CFS but not in patients with MS was\u00a0strongly negatively correlated with pain pressure thresholds and cuff\u00a0pressure thresholds, and positively correlated with temporal summation.<\/p>\n

Limitations:
\nThe main limitations of our study are the relatively small sample sizes,\u00a0its cross-sectional design, and its exploratory nature.<\/p>\n

Conclusions:
\nWe found differences in the characteristics of pain symptoms reported by\u00a0patients with CFS and patients with MS, which suggest different\u00a0underlying mechanisms. Specifically, overactive endogenous pain<\/a>\u00a0facilitation was characteristic of pain in patients with CFS but not in\u00a0patients with MS, suggesting a greater\u00a0role for central sensitization in CFS<\/p>\n

Comment<\/strong>: Phoenix Rising Forum<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Endogenous pain facilitation rather than inhibition differs\u00a0between people with Chronic Fatigue Syndrome, Multiple Sclerosis,\u00a0and controls: An observational study, by\u00a0Simon M. Collin, Jo Nijs, Mira Meeus, Andrea Polli,\u00a0Barbara Willekens, Kelly Ickmans in Pain Physician, May 2017, Volume 20, Issue … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3219,3785,250,1055,3786,2143,2371],"class_list":["post-13165","post","type-post","status-publish","format-standard","hentry","category-news","tag-andrea-polli","tag-barbara-willekens","tag-chronic-pain","tag-k-ickmans","tag-mira-meeus","tag-prof-jo-nijs","tag-simon-m-collin"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3ql","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=13165"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13165\/revisions"}],"predecessor-version":[{"id":13191,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13165\/revisions\/13191"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=13165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=13165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=13165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}