{"id":13370,"date":"2017-06-14T04:32:42","date_gmt":"2017-06-14T04:32:42","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=13370"},"modified":"2017-06-14T04:36:05","modified_gmt":"2017-06-14T04:36:05","slug":"clinical-similarities-between-mecfs-d-lactic-acidosis-a-systematic-review","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/clinical-similarities-between-mecfs-d-lactic-acidosis-a-systematic-review\/","title":{"rendered":"Clinical similarities between ME\/CFS & d-lactic acidosis: a systematic review"},"content":{"rendered":"

Review abstract:<\/strong><\/p>\n

Examining clinical similarities between myalgic encephalomyelitis\/chronic fatigue syndrome and d-lactic acidosis: a systematic review<\/a>, by Amy\u00a0Wallis,\u00a0Michelle\u00a0Ball,
\nSandra\u00a0McKechnie, Henry\u00a0Butt, Donald\u00a0P.\u00a0Lewis and Dorothy\u00a0Bruck in<\/span> Journal of Translational Medicine<\/em> 2017 15:129 [Published: 7\u00a0June\u00a02017]<\/p>\n

Background:
\nThe pursuit for clarity in diagnostic and treatment pathways for the complex, chronic condition of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) continues. This systematic review raises a novel question to explore possible overlapping aetiology in two distinct conditions. Similar neurocognitive symptoms and evidence of d-lactate producing bacteria in ME\/CFS raise questions about shared mechanisms with the acute condition of d-lactic acidosis (d-la).<\/p>\n

Methods:
\nd-la case reports published between 1965 and March 2016 were reviewed for episodes describing both neurological symptoms and high d-lactate levels. Fifty-nine d-la episodes were included in the qualitative synthesis comparing d-la symptoms with ME\/CFS diagnostic criteria. A narrative review of d-la mechanisms and relevance for ME\/CFS was provided.<\/p>\n

Results:
\nThe majority of neurological disturbances reported in d-la episodes overlapped with ME\/CFS symptoms. Of these, the most frequently reported d-la symptoms were motor disturbances that appear more prominent during severe presentations of ME\/CFS. Both patient groups shared a history of gastrointestinal abnormalities and evidence of bacterial dysbiosis, although only preliminary evidence supported the role of lactate-producing bacteria in ME\/CFS.<\/p>\n

Limitations:
\nInterpretation of results are constrained by both the breadth of symptoms included in ME\/CFS diagnostic criteria and the conservative methodology used for d-la symptom classification. Several pathophysiological mechanisms in ME\/CFS were not examined.<\/p>\n

Conclusions:
\nShared symptomatology and underlying microbiota\u2013gut\u2013brain interactions raise the possibility of a continuum of acute (d-la) versus chronic (ME\/CFS) presentations related to d-lactate absorption. Measurement of d-lactate in ME\/CFS is needed to effectively evaluate whether subclinical d-lactate levels affect neurological symptoms in this clinical population.<\/p>\n","protected":false},"excerpt":{"rendered":"

Review abstract: Examining clinical similarities between myalgic encephalomyelitis\/chronic fatigue syndrome and d-lactic acidosis: a systematic review, by Amy\u00a0Wallis,\u00a0Michelle\u00a0Ball, Sandra\u00a0McKechnie, Henry\u00a0Butt, Donald\u00a0P.\u00a0Lewis and Dorothy\u00a0Bruck in Journal of Translational Medicine 2017 15:129 [Published: 7\u00a0June\u00a02017] Background: The pursuit for clarity in diagnostic and … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3279,3808,3806,3807,3233,3805,3803,3804],"class_list":["post-13370","post","type-post","status-publish","format-standard","hentry","category-news","tag-amy-wallis","tag-d-lactic-acidosis","tag-donald-p-lewis","tag-dorothy-bruck","tag-gut-dysbiosis","tag-henry-butt","tag-michelle-ball","tag-sandra-mckechnie"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3tE","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=13370"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13370\/revisions"}],"predecessor-version":[{"id":13371,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13370\/revisions\/13371"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=13370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=13370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=13370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}