{"id":13828,"date":"2017-08-02T07:42:45","date_gmt":"2017-08-02T07:42:45","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=13828"},"modified":"2017-08-02T07:42:45","modified_gmt":"2017-08-02T07:42:45","slug":"cytokine-signature-associated-with-disease-severity-in-cfs-patients","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/cytokine-signature-associated-with-disease-severity-in-cfs-patients\/","title":{"rendered":"Cytokine signature associated with disease severity in CFS patients"},"content":{"rendered":"

Cytokine signature associated with disease severity in chronic fatigue syndrome patients<\/a>, by Jose G. Montoyaa, Tyson H. Holmes, Jill N. Anderson, Holden T. Maecker, Yael Rosenberg-Hasson, Ian J. Valencia, Lily Chu, Jarred W. Younger, Cristina M. Tato, and Mark M. Davis in<\/span> PNAS<\/em> July 31, 2017 <\/span><\/p>\n

Significance:<\/strong><\/p>\n

Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) devastates the lives of millions of people and has remained a mystery illness despite decades of research. It has long been suspected that inflammation is central to its pathogenesis.<\/p>\n

Although only two cytokines were found to be different (TGF-\u03b2 higher and resistin lower) in ME\/CFS patients compared with controls, 17 cytokines correlated with ME\/CFS severity. Thirteen of these cytokines are proinflammatory and may contribute to many of the symptoms these patients experience for several years. Only CXCL9 (MIG) inversely correlated with fatigue duration.<\/p>\n

Research abstract:<\/strong><\/p>\n

Although some signs of inflammation have been reported previously in patients with myalgic encephalomyelitis or chronic fatigue syndrome (ME\/CFS), the data are limited and contradictory. High-throughput methods now allow us to interrogate the human immune system for multiple markers of inflammation at a scale that was not previously possible. To determine whether a signature of serum cytokines could be associated with ME\/CFS and correlated with disease severity and fatigue duration, cytokines of 192 ME\/CFS patients and 392 healthy controls were measured using a 51-multiplex array on a Luminex system.<\/p>\n

Each cytokine\u2019s preprocessed data were regressed on ME\/CFS severity plus covariates for age, sex, race, and an assay property of newly discovered importance: nonspecific binding. On average, TGF-\u03b2 was elevated (P = 0.0052) and resistin was lower (P = 0.0052) in patients compared with controls. Seventeen cytokines had a statistically significant upward linear trend that correlated with ME\/CFS severity:<\/p>\n

CCL11 (Eotaxin-1), CXCL1 (GRO\u03b1), CXCL10 (IP-10), IFN-\u03b3, IL-4, IL-5, IL-7, IL-12p70, IL-13, IL-17F, leptin, G-CSF, GM-CSF, LIF, NGF, SCF, and TGF-\u03b1. Of the 17 cytokines that correlated with severity, 13 are proinflammatory, likely contributing to many of the symptoms experienced by patients and establishing a strong immune system component of the disease. Only CXCL9 (MIG) inversely correlated with fatigue duration.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cytokine signature associated with disease severity in chronic fatigue syndrome patients, by Jose G. Montoyaa, Tyson H. Holmes, Jill N. Anderson, Holden T. Maecker, Yael Rosenberg-Hasson, Ian J. Valencia, Lily Chu, Jarred W. Younger, Cristina M. Tato, and Mark M. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3919,1960,1152,2675,3921,3917,3918,3920,819,1579,3916,1006],"class_list":["post-13828","post","type-post","status-publish","format-standard","hentry","category-news","tag-dr-cristina-tato","tag-dr-jarred-younger","tag-dr-jose-montoya","tag-dr-lily-chu","tag-dr-mark-m-davis","tag-dr-tyson-holmes","tag-dr-yael-rosenberg-hasson","tag-ian-valencia","tag-inflammatory-biomarkers","tag-inflammatory-cytokines","tag-jill-anderson","tag-stanford-mecfs-initiative"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3B2","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=13828"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13828\/revisions"}],"predecessor-version":[{"id":13839,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13828\/revisions\/13839"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=13828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=13828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=13828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}