{"id":13940,"date":"2017-08-10T20:57:19","date_gmt":"2017-08-10T20:57:19","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=13940"},"modified":"2020-02-10T20:59:08","modified_gmt":"2020-02-10T20:59:08","slug":"cytokine-responses-to-exercise-activity-in-patients-with-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/cytokine-responses-to-exercise-activity-in-patients-with-cfs\/","title":{"rendered":"Cytokine responses to exercise &#038; activity in patients with CFS"},"content":{"rendered":"<h3><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/cei.13023\" target=\"_blank\" rel=\"noopener noreferrer\">Cytokine responses to exercise and activity in patients with chronic fatigue syndrome: case control study<\/a>, by LV Clark, M Buckland, G Murphy, N Taylor, V Vleck, C Mein, E. Wozniak, M. Smuk, P.D. White <span style=\"text-decoration: underline;\">in<\/span> <em>Clinical and Experimental Immunology <\/em>August 5, 2017<\/h3>\n<p>&nbsp;<\/p>\n<h3><strong>Summary:<\/strong><\/h3>\n<p>Chronic fatigue syndrome (CFS) is characterized by fatigue after exertion. A systematic review suggested that transforming growth factor beta (TGF-beta) concentrations are often elevated in cases of CFS when compared to healthy controls. This study attempted to replicate this finding, and investigate whether post-exertional symptoms were associated with altered cytokine protein concentrations and their RNA in CFS patients.<\/p>\n<p>Twenty-four patients fulfilling Centers for Disease Control criteria for CFS, but with no comorbid psychiatric disorders, were recruited from two CFS clinics in London, UK. Twenty-one healthy, sedentary controls were matched by gender, age, and other variables. Circulating proteins and RNA were measured for TGF-beta, TNF, IL-8, IL-6 and IL-1beta. We measured six further cytokine protein concentrations (IL-2, IL-4, IL-5, IL-10, IL-12p70, and IFN-gamma). Measures were taken at rest, and before and after both commuting and aerobic exercise.<\/p>\n<p>CFS cases had higher TGF-beta protein levels compared to controls at rest (median (quartiles) = 43.9 (19.2, 61.8) versus 18.9 (16.1, 30.0) ng\/ml) (p = 0.003), and consistently so over a nine-day period. However, this was a spurious finding due to variation between different assay batches.<\/p>\n<p>There were no differences between groups in changes to TGF-beta protein concentrations after either commuting or exercise. All other cytokine protein and RNA levels were similar between cases and controls. Post-exertional symptoms and perceived effort were not associated with any increased cytokines.<\/p>\n<p>We were unable to replicate previously found elevations in circulating cytokine\u00a0concentrations, suggesting that elevated circulating cytokines are not important in the pathophysiology of CFS.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cytokine responses to exercise and activity in patients with chronic fatigue syndrome: case control study, by LV Clark, M Buckland, G Murphy, N Taylor, V Vleck, C Mein, E. Wozniak, M. Smuk, P.D. White in Clinical and Experimental Immunology August &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/cytokine-responses-to-exercise-activity-in-patients-with-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-13940","post","type-post","status-publish","format-standard","hentry","category-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3CQ","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=13940"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13940\/revisions"}],"predecessor-version":[{"id":24352,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/13940\/revisions\/24352"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=13940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=13940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=13940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}