{"id":14534,"date":"2017-10-30T08:00:38","date_gmt":"2017-10-30T08:00:38","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=14534"},"modified":"2017-10-30T08:00:38","modified_gmt":"2017-10-30T08:00:38","slug":"grey-and-white-brain-matter-differences-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/grey-and-white-brain-matter-differences-in-cfs\/","title":{"rendered":"Grey and white brain matter differences in CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Grey and white matter differences in Chronic Fatigue Syndrome\u00a0–\u00a0a voxel-based morphometry study<\/a>, by\u00a0Andreas Finkelmeyer, Jiabao He, Laura Maclachlan,\u00a0Stuart Watson, Peter Gallagher, Julia L. Newton,\u00a0Andrew M. Blamire in<\/span> NeuroImage: Clinical,<\/em> Volume 17, 2018, Pages 24-30 [Preprint\u00a0Available online 28 September 2017]<\/p>\n

Objective:
\nInvestigate global and regional grey and white matter volumes in\u00a0patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance\u00a0imaging (MRI) and recent voxel-based morphometry (VBM) methods.<\/p>\n

Methods:
\nForty-two patients with CFS and thirty healthy volunteers were scanned\u00a0on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented,\u00a0normalized and submitted to a VBM analysis using randomisation methods.\u00a0Group differences were identified in overall segment volumes and\u00a0voxel-wise in spatially normalized grey matter (GM) and white matter\u00a0(WM) segments.<\/p>\n

Results:
\nAccounting for total intracranial volume, patients had larger GM volume\u00a0and lower WM volume. The voxel-wise analysis showed increased GM volume\u00a0in several structures including the amygdala and insula in the patient\u00a0group. Reductions in WM volume in the patient group were seen primarily\u00a0in the midbrain, pons and right temporal lobe.<\/p>\n

Conclusion:
\nElevated GM volume in CFS is seen in areas related to processing of\u00a0interoceptive signals and stress. Reduced WM volume in the patient group\u00a0partially supports earlier findings of WM abnormalities in regions of\u00a0the midbrain and brainstem.<\/p>\n

ME Association comment: MEA Review: Grey and white matter differences in chronic fatigue syndrome<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Grey and white matter differences in Chronic Fatigue Syndrome\u00a0–\u00a0a voxel-based morphometry study, by\u00a0Andreas Finkelmeyer, Jiabao He, Laura Maclachlan,\u00a0Stuart Watson, Peter Gallagher, Julia L. Newton,\u00a0Andrew M. Blamire in NeuroImage: Clinical, Volume 17, 2018, Pages 24-30 [Preprint\u00a0Available online 28 September … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4062,4064,2572,1394,4063,3249,2575,4051,2147,420,4050,3873,1246],"class_list":["post-14534","post","type-post","status-publish","format-standard","hentry","category-news","tag-amygdala","tag-andrew-m-blamire","tag-brainstem","tag-grey-matter-volume","tag-jiabao-he","tag-laura-maclachlan","tag-midbrain","tag-peter-gallagher","tag-prof-andreas-finkelmeyer","tag-prof-julia-newton","tag-stuart-watson","tag-voxel-based-morphometry","tag-white-matter"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3Mq","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=14534"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14534\/revisions"}],"predecessor-version":[{"id":14758,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14534\/revisions\/14758"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=14534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=14534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=14534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}