{"id":14621,"date":"2017-10-17T09:03:26","date_gmt":"2017-10-17T09:03:26","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=14621"},"modified":"2017-10-17T09:03:26","modified_gmt":"2017-10-17T09:03:26","slug":"rethinking-childhood-adversity-in-cfs-2","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/rethinking-childhood-adversity-in-cfs-2\/","title":{"rendered":"Rethinking childhood adversity in CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Rethinking childhood adversity in chronic fatigue syndrome<\/a>, by\u00a0James E Clark, Sean L Davidson, Laura Maclachlan, Julia L Newton, Stuart Watson in<\/span> Fatigue: Biomedicine, Health & Behavior<\/em> [Published online: 10 Oct 2017]<\/p>\n

Background:<\/strong>
\nPrevious studies have consistently shown increased rates of childhood
\nadversity in chronic fatigue syndrome (CFS). However, such
\naetiopathogenic studies of CFS are potentially confounded by
\nco-morbidity and misdiagnosis particularly with depression.<\/p>\n

Purpose:<\/strong>
\nWe examined the relationship between rates of childhood adversity using
\ntwo complimentary approaches (1) a sample of CFS patients who had no
\nlifetime history of depression and (2) a modelling approach.<\/p>\n

Methods:<\/strong>
\nChildhood trauma questionnaire (CTQ) administered to a sample of 52
\nparticipants with chronic fatigue syndrome and 19 controls who did not
\nmeet criteria for a psychiatric disorder (confirmed using the Structured
\nClinical Interview for DSM-IV). Subsequently, Mediation Analysis (Baye’s
\nRules) was used to establish the risk childhood adversity poses for CFS
\nwith and without depression.<\/p>\n

Results:<\/strong>
\nIn a cohort of CFS patients with depression comprehensively excluded,
\nCTQ scores were markedly lower than in all previous studies and, in
\ncontrast to these previous studies, not increased compared with healthy
\ncontrols. Post-hoc analysis showed that CTQ scores correlated with the
\nnumber of depressive symptoms during the lifetime worst period of low
\nmood. The probability of developing CFS given a history of childhood
\ntrauma is 4%, a two-fold increased risk compared to the general
\npopulation. However, much of this risk is mediated by the concomitant
\ndevelopment of major depression.<\/p>\n

Conclusions
\nThe data suggests that previous studies showing a relationship between
\nchildhood adversity and CFS may be attributable to the confounding
\neffects of co-morbid or misdiagnosed depressive disorder.<\/p>\n

Keywords: Childhood adversity, chronic fatigue syndrome, modelling,
\nchildhood trauma, depression<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Rethinking childhood adversity in chronic fatigue syndrome, by\u00a0James E Clark, Sean L Davidson, Laura Maclachlan, Julia L Newton, Stuart Watson in Fatigue: Biomedicine, Health & Behavior [Published online: 10 Oct 2017] Background: Previous studies have consistently shown increased … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[2006,321,2473,1300,3249,420,3574],"class_list":["post-14621","post","type-post","status-publish","format-standard","hentry","category-news","tag-childhood-trauma","tag-depression","tag-james-e-clark","tag-james-watson","tag-laura-maclachlan","tag-prof-julia-newton","tag-sean-davidson"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3NP","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=14621"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14621\/revisions"}],"predecessor-version":[{"id":14636,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14621\/revisions\/14636"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=14621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=14621"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=14621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}