{"id":14764,"date":"2017-11-07T08:38:03","date_gmt":"2017-11-07T08:38:03","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=14764"},"modified":"2017-11-07T08:38:03","modified_gmt":"2017-11-07T08:38:03","slug":"hyperactive-brain-in-cfs-neurometabolites-in-anterior-cingulate-cortex","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/hyperactive-brain-in-cfs-neurometabolites-in-anterior-cingulate-cortex\/","title":{"rendered":"Hyperactive brain in CFS – neurometabolites in anterior cingulate cortex"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Neurometabolites in anterior cingulate cortex in chronic fatigue\u00a0syndrome:\u00a0a magnetic resonance spectroscopy study at 7 Tesla<\/a>, by\u00a0Chi Chen, [Master’s Thesis, Oxford University Sep 2017]<\/p>\n

Background:
\nChronic fatigue syndrome (CFS) is a disorder characterized by prolonged\u00a0physical and mental fatigue that cannot be explained by another\u00a0established medical diagnosis. The anterior cingulate cortex (ACC) and\u00a0putamen are two regions involved in frontal-striatal neural circuitry,\u00a0which may be related to the pathophysiology of CFS. The aim of this\u00a0study was to investigate the concentrations of neurometabolites<\/a>,\u00a0including glutamate<\/a>, gamma-aminobutyric acid <\/a>(GABA) and glutathione<\/a>, in\u00a0 the ACC and putamen<\/a>, using magnetic resonance spectroscopy (MRS) at 7\u00a0Tesla (7T). In addition, this study also aimed to evaluate resting-state\u00a0functional connectivity in CFS with functional magnetic resonance\u00a0imaging (fMRI).<\/p>\n

Methods
\nThis study involved 12 patients who met the Oxford criteria for CFS and\u00a025 healthy controls. Participants rated themselves on the Chalder\u00a0Fatigue Questionnaire (CFQ) and the Beck Depression Inventory (BDI). All\u00a0participants had a single proton (1H) MRS and resting-state fMRI scan\u00a0with a 7T Siemens MAGNETOM scanner (Siemens, Erlangen, Germany) with a\u00a0Nova Medical 32 channel receive array head coil. Spectra were measured
\nfrom voxels in the ACC (20x20x20 mm), putamen (10x16x20 mm) and\u00a0occipital cortex (20x20x20 mm). Spectra were analysed with LCModel to\u00a0obtain absolute concentrations of the neurochemicals. Differences in\u00a0functional connectivity between CFS and healthy participants were tested\u00a0using multivariate exploratory linear optimized decomposition into\u00a0independent components (MELODIC) and dual regression.<\/p>\n

Results
\nConcentrations of putamen glutamate and glutamate+glutamine (Glx) were\u00a0increased in CFS while that of ACC GABA was decreased. Putamen Glx and\u00a0ACC glutamine were negatively associated with the severity of\u00a0self-reported fatigue. There were main effects of CFS diagnosis on\u00a0glutathione (GSH) and total creatine, indicating decreases of these
\nneurometabolites in all the regions studied in CFS patients. In\u00a0addition, the CFS patients demonstrated elevated functional connectivity\u00a0between the default mode network and right supracalcarine cortex,\u00a0precuneus cortex and dorsolateral prefrontal cortex.<\/p>\n

Conclusions
\nThe increased putamen glutamate, decreased ACC GABA and elevated resting\u00a0state functional connectivity of the default mode network suggest a\u00a0hyperactive brain status in CFS. The global decrease of GSH and total\u00a0creatine also suggest that CFS patients may have an abnormal\u00a0bioenergetic status with higher oxidative stress.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Neurometabolites in anterior cingulate cortex in chronic fatigue\u00a0syndrome:\u00a0a magnetic resonance spectroscopy study at 7 Tesla, by\u00a0Chi Chen, [Master’s Thesis, Oxford University Sep 2017] Background: Chronic fatigue syndrome (CFS) is a disorder characterized by prolonged\u00a0physical and mental fatigue that … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4072,1026,2037,2868,4073,4075,1327,4074,306],"class_list":["post-14764","post","type-post","status-publish","format-standard","hentry","category-news","tag-chi-chen","tag-fmri","tag-functional-magnetic-resonance-imaging","tag-gaba","tag-gamma-aminobutyric-acid","tag-hyperactive-brain","tag-metabolites","tag-neurometabolites","tag-oxidative-stress"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3Q8","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14764","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=14764"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14764\/revisions"}],"predecessor-version":[{"id":14778,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14764\/revisions\/14778"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=14764"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=14764"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=14764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}