{"id":14883,"date":"2017-11-15T08:10:57","date_gmt":"2017-11-15T08:10:57","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=14883"},"modified":"2017-11-15T08:10:57","modified_gmt":"2017-11-15T08:10:57","slug":"vitamin-d-status-in-cfsme","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/vitamin-d-status-in-cfsme\/","title":{"rendered":"Vitamin D status in CFS\/ME"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Vitamin D status in chronic fatigue syndrome\/myalgic encephalomyelitis: a cohort study from the North-West of England<\/a>, by KE Earl,\u00a0et al in<\/span> BMJ Open<\/em> 2017 Nov 8;7(11)<\/p>\n

OBJECTIVE:
\nSevere vitamin D deficiency is a recognised cause of skeletal muscle fatigue and myopathy. The aim of this study was to examine whether chronic fatigue syndrome\/myalgic\u2009encephalomyelitis (CFS\/ME) is associated with altered circulating vitamin D metabolites.<\/p>\n

DESIGN:
\nCohort study.<\/p>\n

SETTING:
\nUK university hospital, recruiting from April 2014 to April 2015.<\/p>\n

PARTICIPANTS:
\nNinety-two patients with CFS\/ME and 94 age-matched healthy controls (HCs).<\/p>\n

MAIN OUTCOME MEASURES:
\nThe presence of a significant association between CFS\/ME, fatigue and vitamin D measures.<\/p>\n

RESULTS:
\nNo evidence of a deficiency in serum total 25(OH) vitamin D (25(OH)D2 and 25(OH)D3 metabolites) was evident in individuals with CFS\/ME. Liquid chromatography tandem mass spectrometry (LC-MS\/MS) analysis revealed that total 25(OH)D was significantly higher (p=0.001) in serum of patients with CFS\/ME compared with HCs (60.2 and 47.3\u2009nmol\/L, respectively). Analysis of food\/supplement diaries with WinDiets revealed that the higher total 25(OH) vitamin D concentrations observed in the CFS\/ME group were associated with increased vitamin D intake through use of supplements compared with the control group. Analysis of Chalder Fatigue Questionnaire data revealed no association between perceived fatigue and vitamin D levels.<\/p>\n

CONCLUSIONS:
\nLow serum concentrations of total 25(OH)D do not appear to be a contributing factor to the level of fatigue of CFS\/ME<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Vitamin D status in chronic fatigue syndrome\/myalgic encephalomyelitis: a cohort study from the North-West of England, by KE Earl,\u00a0et al in BMJ Open 2017 Nov 8;7(11) OBJECTIVE: Severe vitamin D deficiency is a recognised cause of skeletal muscle … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4096,1156],"class_list":["post-14883","post","type-post","status-publish","format-standard","hentry","category-news","tag-ke-earl","tag-vitamin-d"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3S3","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14883","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=14883"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14883\/revisions"}],"predecessor-version":[{"id":14893,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/14883\/revisions\/14893"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=14883"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=14883"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=14883"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}