{"id":15030,"date":"2018-01-06T09:40:31","date_gmt":"2018-01-06T09:40:31","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15030"},"modified":"2018-03-06T09:50:59","modified_gmt":"2018-03-06T09:50:59","slug":"transforming-growth-factor-beta-tgf-%ce%b2-in-adolescent-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/transforming-growth-factor-beta-tgf-%ce%b2-in-adolescent-cfs\/","title":{"rendered":"Transforming growth factor beta (TGF-\u03b2) in adolescent CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Transforming growth factor beta (TGF-\u03b2) in adolescent chronic fatigue syndrome<\/a> by VB Wyller, CB Nguyen, JA\u00a0Ludviksen, TE Mollnes in<\/span>\u00a0J Transl Med.<\/em> 2017 Dec 4;15(1):245<\/p>\n

BACKGROUND:
\nChronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescents. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a recent meta-analysis of 38 articles found that of 77 different cytokines measured in plasma, transforming growth factor beta<\/a> (TGF-\u03b2) was the only one that was elevated in patients compared to controls in a sufficient number of articles.<\/p>\n

In the present study we therefore compared the plasma levels of the three TGF-\u03b2 isoforms in adolescent CFS patients and healthy controls. In addition, the study explored associations between TGF-\u03b2 levels, neuroendocrine markers, clinical markers and differentially expressed genes within the CFS group.<\/p>\n

METHODS:
\nCFS patients aged 12-18 years (n = 120) were recruited nation-wide to a single referral center as part of the NorCAPITAL project (ClinicalTrials ID: NCT01040429). A broad case definition of CFS was applied, requiring 3 months of unexplained, disabling chronic\/relapsing fatigue of new onset, whereas no accompanying symptoms were necessary. Healthy controls (n = 68) were recruited from local schools.<\/p>\n

The three isoforms of TGF-\u03b2 (TGF-\u03b21, TGF-\u03b22, TGF-\u03b23) were assayed using multiplex technology. Neuroendocrine markers encompassed plasma and urine levels of catecholamines and cortisol, as well as heart rate variability indices. Clinical markers consisted of questionnaire scores for symptoms of post-exertional malaise, inflammation, fatigue, depression and trait anxiety, as well as activity recordings. Whole blood gene expression was assessed by RNA sequencing in a subgroup of patients (n = 29) and controls (n = 18).<\/p>\n

RESULTS:
\nPlasma levels of all three isoforms of TGF-\u03b2 were equal in the CFS patients and the healthy controls. Subgrouping according to the Fukuda and Canada 2003 criteria of CFS did not reveal differential results. Within the CFS group, all isoforms of TGF-\u03b2 were associated with plasma cortisol, urine norepinephrine and urine epinephrine, and this association pattern was related to fatigue score. Also, TGF-\u03b23 was related to expression of the B cell annotated genes TNFRSF13C and CXCR5.<\/p>\n

CONCLUSIONS:
\nPlasma levels of all TGF-\u03b2 isoforms were not altered in adolescent CFS. However, the TGF-\u03b2 isoforms were associated with neuroendocrine markers, an association related to fatigue score. Furthermore, TGF-\u03b23 might partly mediate an association between plasma cortisol and B cell gene expression. Trial registration Clinical Trials NCT01040429.<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Transforming growth factor beta (TGF-\u03b2) in adolescent chronic fatigue syndrome by VB Wyller, CB Nguyen, JA\u00a0Ludviksen, TE Mollnes in\u00a0J Transl Med. 2017 Dec 4;15(1):245 BACKGROUND: Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescents. The … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[625,4250,793,4252,1873,4251,427,1901,1902,3991,212],"class_list":["post-15030","post","type-post","status-publish","format-standard","hentry","category-news","tag-adolescents","tag-cb-nguyen","tag-cytokine-levels","tag-ja-ludviksen","tag-norcapital-project","tag-te-mollnes","tag-teenagers","tag-tgf-","tag-transforming-growth-factor-beta","tag-vegard-bruun-wyller","tag-young-people"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3Uq","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15030"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15030\/revisions"}],"predecessor-version":[{"id":15764,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15030\/revisions\/15764"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}