{"id":15115,"date":"2018-01-10T10:25:18","date_gmt":"2018-01-10T10:25:18","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15115"},"modified":"2018-01-10T10:25:18","modified_gmt":"2018-01-10T10:25:18","slug":"cfs-me-symptom-based-phenotypes-1-year-treatment-outcomes-in-uk-netherlands","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/cfs-me-symptom-based-phenotypes-1-year-treatment-outcomes-in-uk-netherlands\/","title":{"rendered":"CFS\/ME symptom-based phenotypes &#038; 1 year treatment outcomes in UK &#038; Netherlands"},"content":{"rendered":"<h3><strong>Research abstract:<\/strong><\/h3>\n<p><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022399917308413\" target=\"_blank\" rel=\"noopener\">Chronic fatigue syndrome (CFS\/ME) symptom-based phenotypes\u00a0and 1-year treatment outcomes in two clinical cohorts of\u00a0adult patients in the UK and The Netherlands<\/a>, by\u00a0 Simon M. Collin, Jon Heron, Stephanie Nikolaus, Hans\u00a0Knoop, Esther Crawley <span style=\"text-decoration: underline;\">in<\/span> <em>Journal of Psychosomatic Research<\/em>\u00a0Vol. 104, pp 29-34,\u00a0January 2018<\/p>\n<p>Highlights:<\/p>\n<ul>\n<li>we previously described symptom based CFS\/ME <a href=\"https:\/\/pged.org\/what-is-genotype-what-is-phenotype\/\" target=\"_blank\" rel=\"noopener\">phenotypes<\/a>\u00a0in UK and Dutch patients.<\/li>\n<li>These phenotypes were replicated in the new UK patient cohort.<\/li>\n<li>Patients with multiple symptoms or pain or less likely to respond to treatment.<\/li>\n<li>The same phenotypes and associations were observed in UK and Dutch patients.<\/li>\n<li>The associations were robust to adjustment for severity of illness.<\/li>\n<\/ul>\n<p>Objective:<br \/>\nWe previously described symptom-based chronic fatigue syndrome (CFS\/ME)<a href=\"https:\/\/pged.org\/what-is-genotype-what-is-phenotype\/\" target=\"_blank\" rel=\"noopener\">\u00a0phenotypes<\/a> in clinical assessment data from 7041 UK and 1392 Dutch adult\u00a0CFS\/ME patients. Here we aim to replicate these phenotypes in a more\u00a0recent UK patient cohort, and investigate whether phenotypes are\u00a0associated with 1-year treatment outcome.<\/p>\n<p>Methods:<br \/>\n12 specialist CFS\/ME services (11 UK, 1 NL) recorded the\u00a0presence\/absence of 5 symptoms (muscle pain, joint pain, headache, sore\u00a0throat, and painful lymph nodes) which can occur in addition to the 3\u00a0symptoms (post-exertional malaise, cognitive dysfunction, and<br \/>\ndisturbed\/unrefreshing sleep) that are present for almost all patients.\u00a0Latent Class Analysis (LCA) was used to assign symptom profiles\u00a0(phenotypes). Multinomial logistic regression models were fitted to\u00a0quantify associations between phenotypes and overall change in health\u00a01 year after the start of treatment.<\/p>\n<p>Results:<br \/>\nBaseline data were available for N=918 UK and N=1392 Dutch patients, of\u00a0whom 416 (45.3%) and 912 (65.5%) had 1-year follow-up data,\u00a0respectively. 3- and 4-class phenotypes identified in the previous UK\u00a0patient cohort were replicated in the new UK cohort. UK patients who\u00a0presented with &#8216;polysymptomatic&#8217; and &#8216;pain-only&#8217; phenotypes were 57% and\u00a067% less likely (multinomial odds ratio (MOR) 0.43 (95% CI 0.19-0.94)<br \/>\nand 0.33 (95% CI 0.13-0.84)) to report that their health was &#8216;very much\u00a0better&#8217; or &#8216;much better&#8217; than patients who presented with an\u00a0&#8216;oligosymptomatic&#8217; phenotype. For Dutch patients, polysymptomatic and\u00a0pain-only phenotypes were associated with 72% and 55% lower odds of\u00a0improvement (MOR 0.28 (95% CI 0.11, 0.69) and 0.45 (95% CI 0.21, 0.99))<br \/>\ncompared with oligosymptomatic patients.<\/p>\n<p>Conclusions:<br \/>\nAdult CFS\/ME patients with multiple symptoms or pain symptoms who\u00a0present for specialist treatment are much less likely to report\u00a0favourable treatment outcomes than patients who present with few\u00a0symptoms.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research abstract: Chronic fatigue syndrome (CFS\/ME) symptom-based phenotypes\u00a0and 1-year treatment outcomes in two clinical cohorts of\u00a0adult patients in the UK and The Netherlands, by\u00a0 Simon M. Collin, Jon Heron, Stephanie Nikolaus, Hans\u00a0Knoop, Esther Crawley in Journal of Psychosomatic Research\u00a0Vol. 104, &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/cfs-me-symptom-based-phenotypes-1-year-treatment-outcomes-in-uk-netherlands\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[416,3664,4129,727,2371,4128,2302,1586],"class_list":["post-15115","post","type-post","status-publish","format-standard","hentry","category-news","tag-dr-esther-crawley","tag-hans-knoop","tag-jon-heron","tag-phenotypes","tag-simon-m-collin","tag-stephanie-nikolaus","tag-symptom-profiles","tag-treatment-outcomes"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3VN","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15115"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15115\/revisions"}],"predecessor-version":[{"id":15141,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15115\/revisions\/15141"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15115"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15115"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}