{"id":15137,"date":"2018-01-11T08:38:05","date_gmt":"2018-01-11T08:38:05","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15137"},"modified":"2018-01-11T09:44:17","modified_gmt":"2018-01-11T09:44:17","slug":"cytokine-signatures-in-cfs-patients-a-case-control-study-the-effect-of-anakinra-treatment","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/cytokine-signatures-in-cfs-patients-a-case-control-study-the-effect-of-anakinra-treatment\/","title":{"rendered":"Cytokine signatures in CFS patients: a Case Control Study & the effect of anakinra treatment"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment<\/a>, by\u00a0Megan\u00a0E.\u00a0Roerink,\u00a0Hans\u00a0Knoop,\u00a0Luuk\u00a0J.\u00a0A.\u00a0C.\u00a0Hawinkels,\u00a0Leo\u00a0A.\u00a0B.\u00a0Joosten and\u00a0Jos\u00a0W.\u00a0M.\u00a0van der\u00a0Meer in\u00a0Journal of Translational Medicine 2017 15:267<\/p>\n

Background:
\nCytokine<\/a> disturbances have been suggested to be associated with the Chronic Fatigue Syndrome\/Myalgic encephalomyelitis (CFS\/ME) for decades.<\/p>\n

Methods:
\nFifty female CFS patients were included in a study on the effect of the interleukin-1-receptor antagonist anakinra<\/a> or placebo during 4\u00a0weeks. EDTA plasma was collected from patients before and directly after treatment. At baseline, plasma samples were collected at the same time from 48 healthy, age-matched female neighborhood controls. A panel of 92 inflammatory markers was determined in parallel in 1\u00a0\u03bcL samples using a \u2018proximity extension assay\u2019 (PEA) based immunoassay. Since Transforming growth factor beta (TGF-\u03b2) and interleukin-1 receptor antagonist (IL-1Ra) were not included in this platform, these cytokines were measured with ELISA.<\/p>\n

Results:
\nIn CFS\/ME patients, the \u2018normalized protein expression\u2019 value of IL-12p40 and CSF-1 was significantly higher (p value 0.0042 and 0.049, respectively). Furthermore, using LASSO regression, a combination of 47 markers yielded a prediction model with a corrected AUC of 0.73. After correction for multiple testing, anakinra had no effect on circulating cytokines. TGF-\u03b2 did not differ between patients and controls.<\/p>\n

Conclusions:
\nIn conclusion, this study demonstrated increased IL-12p40 and CSF-1 concentrations in CFS\/ME patients in addition to a set of predictive biomarkers. There was no effect of anakinra on circulating cytokines other than IL-1Ra.<\/p>\n

Trial Registration: ClinicalTrials.gov Identifier: NCT02108210, Registered April 2014<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment, by\u00a0Megan\u00a0E.\u00a0Roerink,\u00a0Hans\u00a0Knoop,\u00a0Luuk\u00a0J.\u00a0A.\u00a0C.\u00a0Hawinkels,\u00a0Leo\u00a0A.\u00a0B.\u00a0Joosten and\u00a0Jos\u00a0W.\u00a0M.\u00a0van der\u00a0Meer in\u00a0Journal of Translational Medicine 2017 15:267 Background: Cytokine disturbances have been suggested to be associated with the Chronic … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3577,1900,4131,3664,4133,3578,1939,4130,4132,3299],"class_list":["post-15137","post","type-post","status-publish","format-standard","hentry","category-news","tag-anakinra","tag-circulating-cytokines","tag-ewald-m-bronkhorst","tag-hans-knoop","tag-henk-a-mouthaan","tag-interleukin-1-receptor-antagonist","tag-jwm-van-der-meer","tag-leo-a-b-joosten","tag-luuk-jac-hawinkels","tag-megan-e-roerink"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3W9","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15137"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15137\/revisions"}],"predecessor-version":[{"id":15147,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15137\/revisions\/15147"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}