{"id":15308,"date":"2018-01-24T07:43:41","date_gmt":"2018-01-24T07:43:41","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15308"},"modified":"2018-01-24T07:47:39","modified_gmt":"2018-01-24T07:47:39","slug":"longitudinal-associations-of-lymphocyte-subsets-with-clinical-outcomes-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/longitudinal-associations-of-lymphocyte-subsets-with-clinical-outcomes-in-cfs\/","title":{"rendered":"Longitudinal associations of lymphocyte subsets with clinical outcomes in CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/p>\n

Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome<\/a>, by\u00a0 Melissa L. Mehalick,\u00a0Karen B. Schmaling\u00a0, Daniel E. Sabath,\u00a0& Dedra S. Buchwald in\u00a0Fatigue: Biomedicine, Health & Behavior 2018 pp 1-12\u00a0 [Published online: 12 Jan 2018]<\/p>\n

Background:<\/p>\n

Chronic fatigue syndrome (CFS) is characterized by prolonged fatigue and other physical and neurocognitive symptoms. Some studies suggest that CFS is accompanied by disruptions in the number and function of various lymphocytes<\/a>. However, it is not clear which lymphocytes might influence CFS symptoms.<\/p>\n

Purpose:<\/p>\n

To determine if patient reported fatigue symptoms and physical functioning scores significantly changed across time with lymphocyte counts as evidence of a relation among chronic fatigue symptoms and the immune response<\/a>.<\/p>\n

Methods:<\/p>\n

The current longitudinal, naturalistic study assessed the cellular expression of three lymphocyte subtypes \u2013 natural killer (NK) cells (CD3\u2009\u2212\u2009CD16+ and CD3\u2009\u2212\u2009CD56+) and na\u00efve T cells (CD4\u2009+\u2009CD45RA+) \u2013 to determine whether changes in lymphocytes at 4 time points across 18 months were associated with clinical outcomes, including CFS symptoms, physical functioning, and vitality, among patients with chronic fatigue. Latent growth curve models were used to examine the longitudinal relationship between lymphocytes and clinical outcomes.<\/p>\n

Results:<\/p>\n

Ninety-three patients with Fukuda-based CFS and seven with non-CFS fatigue provided study data. Results indicated that higher proportions of na\u00efve T cells and lower proportions of NK cells were associated with worse physical functioning, whereas higher proportions of NK cells (CD3\u2009\u2212\u2009CD16+) and lower proportions of na\u00efve T cells were associated with fewer CFS symptoms.<\/p>\n

Conclusion:<\/p>\n

These findings suggest that lymphocytes are modestly related to clinical outcomes over time.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome, by\u00a0 Melissa L. Mehalick,\u00a0Karen B. Schmaling\u00a0, Daniel E. Sabath,\u00a0& Dedra S. Buchwald in\u00a0Fatigue: Biomedicine, Health & Behavior 2018 pp 1-12\u00a0 [Published online: 12 Jan 2018] Background: … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4165,4164,927,4166,23,4167,722,498],"class_list":["post-15308","post","type-post","status-publish","format-standard","hentry","category-news","tag-daniel-e-sabath","tag-dedra-s-buchwald","tag-immune-dysfyunction","tag-karen-b-schmaling","tag-lymphocytes","tag-melissa-l-mehalick","tag-natural-killer-cells","tag-t-cell"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3YU","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15308"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15308\/revisions"}],"predecessor-version":[{"id":15321,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15308\/revisions\/15321"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}