{"id":15326,"date":"2018-01-26T14:57:01","date_gmt":"2018-01-26T14:57:01","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15326"},"modified":"2018-01-26T14:57:01","modified_gmt":"2018-01-26T14:57:01","slug":"eukaryotes-in-the-gut-microbiota-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/eukaryotes-in-the-gut-microbiota-in-me-cfs\/","title":{"rendered":"Eukaryotes in the gut microbiota in ME\/CFS"},"content":{"rendered":"<h3><strong>Research abstract:<\/strong><\/h3>\n<p><a href=\"https:\/\/peerj.com\/articles\/4282\/\" target=\"_blank\" rel=\"noopener\">Eukaryotes in the gut microbiota in myalgic encephalomyelitis\/chronic fatigue syndrome<\/a>, by Alexandra H. Mandarano, Ludovic Giloteaux, Betsy A. Keller, Susan M. Levine, Maureen R. Hanson <span style=\"text-decoration: underline;\">in<\/span> \u00a0<em><span class=\"self-citation-journal\">PeerJ<\/span><\/em> <span class=\"self-citation-volume\">6<\/span>:<span class=\"self-citation-elocation\">e4282 [<\/span>January 22, 2018]<\/p>\n<p>Patients with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) often suffer from gastrointestinal symptoms and many are diagnosed with irritable bowel syndrome (IBS).<\/p>\n<p>Previous studies, including from our laboratory, have demonstrated that the ME\/CFS gut bacterial composition is altered and less diverse when compared to healthy individuals. Patients have increased biomarkers of inflammation and leaky gut syndrome.<\/p>\n<p>To further investigate <a href=\"https:\/\/en.wikipedia.org\/wiki\/Dysbiosis\" target=\"_blank\" rel=\"noopener\">dysbiosis<\/a> in the ME\/CFS gut microbiome, we sought to characterize the <a href=\"https:\/\/simple.wikipedia.org\/wiki\/Eukaryote\" target=\"_blank\" rel=\"noopener\">eukaryotes<\/a> present in the gut of 49 individuals with ME\/CFS and 39 healthy controls.<\/p>\n<p>Using 18S rRNA sequencing, we have identified eukaryotes in stool samples of 17 healthy individuals and 17 ME\/CFS patients. Our analysis demonstrates a small, nonsignificant decrease in eukaryotic diversity in ME\/CFS patients compared to healthy individuals.<\/p>\n<p>In addition, ME\/CFS patients show a nonsignificant increase in the ratio of fungal phyla Basidiomycota to Ascomycota, which is consistent with ongoing inflammation in ME\/CFS. We did not identify specific eukaryotic taxa that are associated with ME\/CFS disease status.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research abstract: Eukaryotes in the gut microbiota in myalgic encephalomyelitis\/chronic fatigue syndrome, by Alexandra H. Mandarano, Ludovic Giloteaux, Betsy A. Keller, Susan M. Levine, Maureen R. Hanson in \u00a0PeerJ 6:e4282 [January 22, 2018] Patients with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/eukaryotes-in-the-gut-microbiota-in-me-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4175,3184,2530,4173,4174,234,1325,608,610,1352,2822,2823],"class_list":["post-15326","post","type-post","status-publish","format-standard","hentry","category-news","tag-alexandra-h-mandarano","tag-betsy-a-keller","tag-dr-susan-levine","tag-eukaryotes","tag-fungal-phyla","tag-gastrointestinal-disorder","tag-gut-microbiome","tag-ibs","tag-irritable-bowel-syndrome","tag-leaky-gut","tag-ludovic-giloteaux","tag-prof-maureen-hanson"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-3Zc","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15326"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15326\/revisions"}],"predecessor-version":[{"id":15342,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15326\/revisions\/15342"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}