{"id":15514,"date":"2018-02-15T08:51:41","date_gmt":"2018-02-15T08:51:41","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15514"},"modified":"2018-06-15T21:06:24","modified_gmt":"2018-06-15T21:06:24","slug":"value-of-circulating-cytokine-profiling-during-submaximal-exercise-testing-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/value-of-circulating-cytokine-profiling-during-submaximal-exercise-testing-in-me-cfs\/","title":{"rendered":"Value of circulating cytokine profiling during submaximal exercise testing in ME\/CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Value of circulating cytokine profiling during submaximal exercise testing in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome<\/a>, by\u00a0Kegan J. Moneghetti, Mehdi Skhiri, K\u00e9vin Contrepois, Yukari Kobayashi, Holden Maecker, Mark Davis, Michael Snyder, Francois Haddad & Jose G. Montoya in<\/span> Nature, Scientific Reports<\/em>\u00a08: 2779 (2018) [Published online 9 February 2018]<\/p>\n

Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME\/CFS) is a heterogeneous syndrome in which patients often experience severe fatigue and malaise following exertion.<\/p>\n

Immune and cardiovascular dysfunction have been postulated to play a role in the pathophysiology. We therefore, examined whether cytokine<\/a> profiling or cardiovascular testing following exercise would differentiate patients with ME\/CFS.<\/p>\n

Twenty-four ME\/CFS patients were matched to 24 sedentary controls and underwent cardiovascular and circulating immune profiling.<\/p>\n

Cardiovascular analysis included echocardiography<\/a>, cardiopulmonary exercise<\/a> and endothelial function<\/a> testing. Cytokine and growth factor profiles were analyzed using a 51-plex Luminex bead kit<\/a> at baseline and 18\u2009hours following exercise.<\/p>\n

Cardiac structure and exercise capacity were similar between groups. Sparse partial least square discriminant analyses of cytokine profiles 18\u2009hours post exercise offered the most reliable discrimination between ME\/CFS and controls (\u03ba\u2009=\u20090.62(0.34,0.84)).<\/p>\n

The most discriminatory cytokines post exercise were CD40L, platelet activator inhibitor, interleukin 1-\u03b2, interferon-\u03b1 and CXCL1.<\/p>\n

In conclusion, cytokine profiling following exercise may help differentiate patients with ME\/CFS from sedentary controls.<\/p>\n

Scope<\/strong> blog post from Stanford Medicine, by Bruce Goldman,\u00a0February 15, 2018: Exercise elevates blood signature difference between people with, without chronic fatigue syndrome<\/a><\/p>\n

Health rising blog post<\/strong>, by Cort Johnson, 5 March 2018: Stanford Exercise Study Shows Different Immune Response in Chronic Fatigue Syndrome (ME\/CFS)<\/a><\/p>\n

Solve ME\/CFS Initiative blog post:<\/strong> Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in ME\/CFS, March 2018<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Value of circulating cytokine profiling during submaximal exercise testing in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome, by\u00a0Kegan J. Moneghetti, Mehdi Skhiri, K\u00e9vin Contrepois, Yukari Kobayashi, Holden Maecker, Mark Davis, Michael Snyder, Francois Haddad & Jose G. Montoya in Nature, Scientific … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1250,113,3429,4207,4208,4206,4210,1306,1002,4012,1081,4209],"class_list":["post-15514","post","type-post","status-publish","format-standard","hentry","category-news","tag-cardiovascular-function","tag-cytokines","tag-dr-michael-snyder","tag-francois-haddad","tag-holden-maecker","tag-kegan-j-moneghetti","tag-kevin-contrepois","tag-mark-davis","tag-mehdi-skhiri","tag-prof-jose-montoya","tag-submaximal-exercise-test","tag-yukari-kobayashi"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-42e","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15514"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15514\/revisions"}],"predecessor-version":[{"id":17114,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15514\/revisions\/17114"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}