{"id":15709,"date":"2018-03-09T08:38:11","date_gmt":"2018-03-09T08:38:11","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15709"},"modified":"2018-04-30T06:02:28","modified_gmt":"2018-04-30T06:02:28","slug":"association-of-cfs-with-premature-telomere-attrition-accelerated-ageing","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/association-of-cfs-with-premature-telomere-attrition-accelerated-ageing\/","title":{"rendered":"Association of CFS with premature telomere attrition (& accelerated ageing)"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Association of chronic fatigue syndrome with premature telomere attrition<\/a>, by Mangalathu S. Rajeevan, Janna Murray, Lisa Oakley, Jin-Mann S. Lin, Elizabeth R. Unger in<\/span> Journal of Translational Medicine <\/em>Vol 16, #1, p 44 [Published: 27 February 2018]<\/p>\n

Backgro\"\"und:<\/strong><\/p>\n

Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a severely debilitating condition of unknown etiology. The symptoms and risk factors of ME\/CFS share features of accelerated aging implicated in several diseases. Using telomere<\/a> length as a marker, this study was performed to test the hypothesis that ME\/CFS is associated with accelerated aging.<\/p>\n

Methods:<\/strong><\/p>\n

Participant (n=639) data came from the follow-up time point of the Georgia CFS surveillance study. Using the 1994 CFS Research Case Definition with questionnaire-based subscale thresholds for fatigue, function, and symptoms, participants were classified into four illness groups: CFS if all criteria were met (n=64), CFS-X if CFS with exclusionary conditions (n=77), ISF (insufficient symptoms\/fatigue) if only some criteria were met regardless of exclusionary conditions (n=302), and NF (non-fatigued) if no criteria and no exclusionary conditions (n=196).<\/p>\n

Relative telomere length (T\/S ratio) was measured using DNA from whole blood and real-time PCR. General linear models were used to estimate the association of illness groups or T\/S ratio with demographics, biological measures and covariates with significance set at p<0.05.<\/p>\n

Results:<\/strong><\/p>\n

The mean T\/S ratio differed significantly by illness group (p=0.0017); the T\/S ratios in CFS (0.90 p\/m 0.03) and ISF (0.94 p\/m 0.02) were each significantly lower than in NF (1.06 p\/m 0.04). Differences in T\/S ratio by illness groups remained significant after adjustment for covariates of age, sex, body mass index, waist-hip ratio, post-exertional malaise and education attainment.<\/p>\n

Telomere length was shorter by 635, 254 and 424 base pairs in CFS, CFS-X and ISF, respectively, compared to NF. This shorter telomere length translates to roughly 10.1-20.5, 4.0-8.2 and 6.6-13.7 years of additional aging in CFS, CFS-X and ISF compared to NF respectively. Further, stratified analyses based on age and sex demonstrated that the association of ME\/CFS with short telomeres is largely moderated by female subjects<45 years old.<\/p>\n

Conclusions:<\/strong><\/p>\n

This study found a significant association of ME\/CFS with premature telomere attrition that is largely moderated by female subjects<45 years old. Our results indicate that ME\/CFS could be included in the list of conditions associated with accelerated aging. Further work is needed to evaluate the functional significance of accelerated aging in ME\/CFS.<\/p>\n

More info<\/strong>: The association of Chronic Fatigue Syndrome with premature telomere attrition<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Association of chronic fatigue syndrome with premature telomere attrition, by Mangalathu S. Rajeevan, Janna Murray, Lisa Oakley, Jin-Mann S. Lin, Elizabeth R. Unger in Journal of Translational Medicine Vol 16, #1, p 44 [Published: 27 February 2018] Background: … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[2540,4243,4242,4244,4245,4254,4240],"class_list":["post-15709","post","type-post","status-publish","format-standard","hentry","category-news","tag-dr-elizabeth-unger","tag-janna-murray","tag-jin-mann-s-lin","tag-lisa-oakley","tag-mangalathu-s-rajeevan","tag-premature-ageing","tag-telomere-length"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-45n","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15709"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15709\/revisions"}],"predecessor-version":[{"id":16326,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15709\/revisions\/16326"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15709"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}