{"id":15819,"date":"2018-03-12T07:49:05","date_gmt":"2018-03-12T07:49:05","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15819"},"modified":"2018-03-12T07:50:34","modified_gmt":"2018-03-12T07:50:34","slug":"does-the-microbiome-virome-contribute-to-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/does-the-microbiome-virome-contribute-to-me-cfs\/","title":{"rendered":"Does the microbiome & virome contribute to ME\/CFS?"},"content":{"rendered":"

Review abstract:<\/strong><\/h3>\n

Does the microbiome and virome contribute to myalgic\u00a0encephalomyelitis\/chronic fatigue syndrome?<\/a> by\u00a0Fiona Newberry, Shen-Yuan Hsieh, Tom Wileman,\u00a0Simon R. Carding in<\/span> Clinical Science<\/em>\u00a0Vol 135, #5, pp 523-542 [Published online\u00a0March 9, 2018]<\/p>\n

Myalgic encephalomyelitis (ME)\/chronic fatigue syndrome (CFS) (ME\/CFS)\u00a0is a disabling and debilitating disease of unknown aetiology. It is a\u00a0heterogeneous disease characterized by various inflammatory, immune, viral, neurological and endocrine symptoms.<\/p>\n

Several microbiome studies\u00a0have described alterations in the bacterial component of the microbiome\u00a0(dysbiosis) consistent with a possible role in disease development.\u00a0 However, in focusing on the bacterial components of the microbiome,\u00a0these studies have neglected the viral constituent known as the virome.<\/p>\n

Viruses, particularly those infecting bacteria (bacteriophages), have\u00a0the potential to alter the function and structure of the microbiome via\u00a0gene transfer and host lysis. Viral-induced microbiome changes can\u00a0directly and indirectly influence host health and disease. The\u00a0contribution of viruses towards disease pathogenesis is therefore an\u00a0important area for research in ME\/CFS. Recent advancements in sequencing\u00a0technology and bioinformatics now allow more comprehensive and inclusive\u00a0investigations of human microbiomes.<\/p>\n

However, as the number of\u00a0microbiome studies increases, the need for greater consistency in study\u00a0design and analysis also increases. Comparisons between different ME\/CFS microbiome studies are difficult because of differences in patient\u00a0selection and diagnosis criteria, sample processing, genome sequencing\u00a0and downstream bioinformatics analysis. It is therefore important that\u00a0microbiome studies adopt robust, reproducible and consistent study\u00a0design to enable more reliable and valid comparisons and conclusions to\u00a0be made between studies.<\/p>\n

\"\"This article provides a comprehensive review of\u00a0the current evidence supporting microbiome alterations in ME\/CFS\u00a0patients. Additionally, the pitfalls and challenges associated with\u00a0microbiome studies are discussed.<\/p>\n","protected":false},"excerpt":{"rendered":"

Review abstract: Does the microbiome and virome contribute to myalgic\u00a0encephalomyelitis\/chronic fatigue syndrome? by\u00a0Fiona Newberry, Shen-Yuan Hsieh, Tom Wileman,\u00a0Simon R. Carding in Clinical Science\u00a0Vol 135, #5, pp 523-542 [Published online\u00a0March 9, 2018] Myalgic encephalomyelitis (ME)\/chronic fatigue syndrome (CFS) (ME\/CFS)\u00a0is a disabling … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4255,1325,3477,4256,4257,2790],"class_list":["post-15819","post","type-post","status-publish","format-standard","hentry","category-news","tag-fiona-newberry","tag-gut-microbiome","tag-prof-simon-carding","tag-shen-yuan-hsieh","tag-tom-wileman","tag-virome"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-479","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15819"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15819\/revisions"}],"predecessor-version":[{"id":15822,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15819\/revisions\/15822"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}