{"id":15886,"date":"2018-03-19T08:47:12","date_gmt":"2018-03-19T08:47:12","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15886"},"modified":"2018-03-19T08:55:57","modified_gmt":"2018-03-19T08:55:57","slug":"immunoadsorption-to-remove-s2-adrenergic-receptor-antibodies-in-cfs-me","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/immunoadsorption-to-remove-s2-adrenergic-receptor-antibodies-in-cfs-me\/","title":{"rendered":"Immunoadsorption to remove \u00df2 adrenergic receptor antibodies in CFS\/ME"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Immunoadsorption to remove \u00df2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS\/ME<\/a>, by Carmen Scheibenbogen, Madlen Loebel, Helma Freitag, Anne Krueger, Sandra Bauer, Michaela Antelmann, Wolfram Doehner, Nadja Scherbakov, Harald Heidecke, Petra Reinke, Hans-Dieter Volk, Patricia Grabowski in<\/span> PLoS One<\/em>. 2018 Mar 15;13(3):e0193672<\/p>\n

INTRODUCTION:
\nInfection-triggered disease onset, chronic immune activation and autonomic dysregulation in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME) point to an autoimmune disease<\/a> directed against neurotransmitter receptors<\/a>. We had observed elevated autoantibodies against \u00df2 adrenergic receptors, and muscarinic 3 and 4 acetylcholine receptors in a subset of patients. Immunoadsorption<\/a> (IA) was shown to be effective in removing autoantibodies and improve outcome in various autoimmune diseases.<\/p>\n

\"\"<\/p>\n

METHODS:
\n10 patients with post-infectious CFS\/ME and elevated \u00df2 autoantibodies were treated with IA with an IgG-binding column for 5 days. We assessed severity of symptoms as outcome parameter by disease specific scores. Antibodies were determined by ELISA and B cell phenotype by flow cytometry.<\/p>\n

RESULTS:
\nIgG levels dropped to median 0.73 g\/l (normal 7-16 g\/l) after the 4th cycle of IA, while IgA and IgM levels remained unchanged. Similarly, elevated \u00df2 IgG antibodies rapidly decreased during IA in 9 of 10 patients. Also 6 months later \u00df2 autoantibodies were significantly lower compared to pretreatment. Frequency of memory B cells significantly decreased and frequency of plasma cells increased after the 4th IA cycle. A rapid improvement of symptoms was reported by 7 patients during the IA. 3 of these patients had long lasting moderate to marked improvement for 6-12+ months, 2 patients had short improvement only and 2 patients improved for several months following initial worsening.<\/p>\n

CONCLUSIONS:
\nIA can remove autoantibodies against \u00df2 adrenergic receptor and lead to clinical improvement. B cell phenotyping provides evidence for an effect of IA on memory B cell development. Data from our pilot trial warrants further studies in CFS\/ME.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Immunoadsorption to remove \u00df2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS\/ME, by Carmen Scheibenbogen, Madlen Loebel, Helma Freitag, Anne Krueger, Sandra Bauer, Michaela Antelmann, Wolfram Doehner, Nadja Scherbakov, Harald Heidecke, Petra Reinke, Hans-Dieter Volk, Patricia Grabowski in … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[1427,4267,4266,2263,4268],"class_list":["post-15886","post","type-post","status-publish","format-standard","hentry","category-news","tag-autoimmune-disorders","tag-carmen-scheibenbogen","tag-immunoadsorption","tag-neurotransmitter","tag-patricia-grabowski"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-48e","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15886","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15886"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15886\/revisions"}],"predecessor-version":[{"id":15910,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15886\/revisions\/15910"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15886"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15886"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}