{"id":15974,"date":"2018-04-09T07:16:03","date_gmt":"2018-04-09T07:16:03","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=15974"},"modified":"2018-04-09T07:16:03","modified_gmt":"2018-04-09T07:16:03","slug":"circulating-extracellular-vesicles-as-potential-biomarkers-in-cfs-me","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/circulating-extracellular-vesicles-as-potential-biomarkers-in-cfs-me\/","title":{"rendered":"Circulating extracellular vesicles as potential biomarkers in CFS\/ME"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome\/ myalgic encephalomyelitis: an exploratory pilot study<\/a>, by\u00a0Jes\u00fas Castro-Marrero, Esther Serrano-Pertierra, Myriam Oliveira-Rodr\u00edguez, Maria Cleof\u00e9 Zaragoza, Alba Mart\u00ednez-Mart\u00ednez, Mar\u00eda del Carmen Blanco-L\u00f3pez\u00a0& Jos\u00e9 Alegre in<\/span> Journal of Extracellular Vesicles <\/em>Volume 7, 2018 – Issue 1 \u00a0<\/em>[Published online: 22 Mar 2018]<\/p>\n

Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME) is an acquired, complex and multisystem condition of unknown etiology, no established diagnostic lab tests and no universally FDA-approved drugs for treatment.<\/p>\n

CFS\/ME is characterised by unexplicable disabling fatigue and is often also associated with numerous core symptoms. A growing body of evidence suggests that extracellular vesicles<\/a> (EVs) play a role in cell-to-cell communication, and are involved in both physiological and pathological processes. To date, no data on EV biology in CFS\/ME are as yet available.<\/p>\n

The aim of this study was to isolate and characterise blood-derived EVs in CFS\/ME. Blood samples were collected from 10 Spanish CFS\/ME patients and 5 matched healthy controls (HCs), and EVs were isolated from the serum using a polymer-based method. Their protein cargo, size distribution and concentration were measured by Western blot and nanoparticle tracking analysis. Furthermore, EVs were detected using a lateral flow immunoassay based on biomarkers CD9 and CD63.<\/p>\n

We found that the amount of EV-enriched fraction was significantly higher in CFS\/ME subjects than in HCs (p\u00a0=\u00a00.007) and that EVs were significantly smaller in CFS\/ME patients (p\u00a0=\u00a00.014). Circulating EVs could be an emerging tool for biomedical research in CFS\/ME.<\/p>\n

These findings provide preliminary evidence that blood-derived EVs may distinguish CFS\/ME patients from HCs. This will allow offer new opportunities and also may open a new door to identifying novel potential biomarkers and therapeutic approaches for the condition.<\/p>\n

Read full article<\/a><\/p>\n

More about extracellular vesicles<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome\/ myalgic encephalomyelitis: an exploratory pilot study, by\u00a0Jes\u00fas Castro-Marrero, Esther Serrano-Pertierra, Myriam Oliveira-Rodr\u00edguez, Maria Cleof\u00e9 Zaragoza, Alba Mart\u00ednez-Mart\u00ednez, Mar\u00eda del Carmen Blanco-L\u00f3pez\u00a0& Jos\u00e9 Alegre in Journal of Extracellular Vesicles … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4290,4170,4286,4281,4284,4289,4283,4287,4288,4285,4282],"class_list":["post-15974","post","type-post","status-publish","format-standard","hentry","category-news","tag-alba-martinez-martinez","tag-biomarker","tag-esther-serrano-pertierra","tag-extracellular-vesicles","tag-jesus-castro-marrero","tag-jose-alegre","tag-lateral-flow-immunoassay-system","tag-maria-cleofe-zaragoza","tag-maria-del-carmen-blanco-lopez","tag-myriam-oliveira-rodriguez","tag-tetraspanins"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-49E","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=15974"}],"version-history":[{"count":4,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15974\/revisions"}],"predecessor-version":[{"id":16111,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/15974\/revisions\/16111"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=15974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=15974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=15974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}