{"id":16128,"date":"2018-04-12T06:18:16","date_gmt":"2018-04-12T06:18:16","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=16128"},"modified":"2018-04-12T06:18:16","modified_gmt":"2018-04-12T06:18:16","slug":"disequilibrium-orthostatic-intolerance-in-patients-with-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/disequilibrium-orthostatic-intolerance-in-patients-with-me-cfs\/","title":{"rendered":"Disequilibrium &#038; orthostatic intolerance in patients with ME (CFS)"},"content":{"rendered":"<p><strong>Research abstract:<\/strong><\/p>\n<p><a href=\"http:\/\/www.journal-of-cardiology.com\/article\/S0914-5087(18)30058-3\/fulltext\" target=\"_blank\" rel=\"noopener\">The etiologic relation between disequilibrium and orthostatic intolerance in patients with\u00a0myalgic encephalomyelitis\u00a0(chronic fatigue syndrome)<\/a> by\u00a0K Miwa,\u00a0Y Inoue\u00a0<span style=\"text-decoration: underline;\">in<\/span> <em>J Cardiol<\/em>. 2018 Mar 24. pii: S0914-5087(18)30058-3 [Epub ahead of print]<\/p>\n<p><strong>Highlights: <\/strong><\/p>\n<ul>\n<li>Disequilibrium should be recognized as the important cause for orthostatic intolerance (OI).<\/li>\n<li>Most patients with disequilibrium report sitting intolerance as well as OI.<\/li>\n<li>Disequilibrium appears to be more influential cause for OI than postural orthostatic tachycardia.<\/li>\n<\/ul>\n<p><strong>Background:<\/strong><br \/>\n<a href=\"https:\/\/en.wikipedia.org\/wiki\/Orthostatic_intolerance\" target=\"_blank\" rel=\"noopener\">Orthostatic intolerance<\/a> (OI) causes a marked reduction in the activities of daily living in patients with\u00a0myalgic encephalomyelitis\u00a0(ME) or\u00a0chronic fatigue syndrome.<\/p>\n<p>Most symptoms of OI are thought to be related to <a href=\"https:\/\/spinecentre.com.au\/hypoperfusion-what-you-dont-know-can-hurt-you\/\" target=\"_blank\" rel=\"noopener\">cerebral hypo-perfusion<\/a> and sympathetic activation. Because postural stability is an essential element of orthostatic tolerance, <a href=\"https:\/\/en.wikipedia.org\/wiki\/Disequilibrium_(medicine)\" target=\"_blank\" rel=\"noopener\">disequilibrium<\/a> may be involved in the etiology of OI.<\/p>\n<p><strong>Methods and Results:<\/strong><br \/>\nThe study comprised 44 patients with ME (men, 11 and women, 33; mean age, 37\u00b19 years), who underwent neurological examinations and 10-min standing and sitting tests.<\/p>\n<p>Symptoms of OI were detected in 40 (91%) patients and those of sitting intolerance were detected in 30 (68%). Among the 40 patients with OI, disequilibrium with instability on standing with their feet together and eyes shut, was detected in 13 (32.5%) patients and hemodynamic dysfunction during the standing test was detected in 19 (47.5%); both of these were detected in 7 (17.5%) patients.<\/p>\n<p>Compared with 31 patients without disequilibrium, 13 (30%) patients with disequilibrium more prevalently reported symptoms during both standing (100% vs. 87%, p=0.43) and sitting (92% vs. 58%, p=0.06) tests. Several (46% vs. 3%, p&lt;0.01) patients failed to complete the 10-min standing test, and some (15% vs. 0%, p=0.15) failed to complete the 10-min sitting test.<\/p>\n<p>Among the seven patients with both hemodynamic dysfunction during the standing test and disequilibrium, three (43%) failed to complete the standing test. Among the 6 patients with disequilibrium only, 3 (50%) failed while among the 12 patients with hemodynamic dysfunction only, including 8 patients with postural orthostatic tachycardia, none (0%, p=0.02) failed.<\/p>\n<p><strong>Conclusion:<\/strong><br \/>\nPatients with ME and disequilibrium reported not only OI but also sitting intolerance. Disequilibrium should be recognized as an important cause of OI and appears to be a more influential cause for OI than postural orthostatic tachycardia in patients with ME.<\/p>\n<p>Link: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29588088<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research abstract: The etiologic relation between disequilibrium and orthostatic intolerance in patients with\u00a0myalgic encephalomyelitis\u00a0(chronic fatigue syndrome) by\u00a0K Miwa,\u00a0Y Inoue\u00a0in J Cardiol. 2018 Mar 24. pii: S0914-5087(18)30058-3 [Epub ahead of print] Highlights: Disequilibrium should be recognized as the important cause for &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/disequilibrium-orthostatic-intolerance-in-patients-with-me-cfs\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4321,2844,493,492,4323,4322],"class_list":["post-16128","post","type-post","status-publish","format-standard","hentry","category-news","tag-disequilibrium","tag-k-miwa","tag-oi","tag-orthostatic-intolerance","tag-sitting-intolerance","tag-y-inoue"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4c8","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=16128"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16128\/revisions"}],"predecessor-version":[{"id":16155,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16128\/revisions\/16155"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=16128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=16128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=16128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}