{"id":16173,"date":"2018-04-19T08:07:03","date_gmt":"2018-04-19T08:07:03","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=16173"},"modified":"2018-04-19T08:07:03","modified_gmt":"2018-04-19T08:07:03","slug":"weighted-standing-time-test-as-a-measure-of-orthostatic-intolerance-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/weighted-standing-time-test-as-a-measure-of-orthostatic-intolerance-in-me-cfs\/","title":{"rendered":"Weighted Standing Time test as a measure of orthostatic intolerance in ME\/CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/h3>\n

Weighting of orthostatic intolerance time measurements with\u00a0standing difficulty score stratifies ME\/CFS symptom severity\u00a0and analyte detection<\/a>, by\u00a0Alice M. Richardson, Don P. Lewis, Badia Kita, Helen\u00a0Ludlow, Nigel P. Groome, Mark P. Hedger, David M. de\u00a0Kretser, Brett A. Lidbury in<\/span> Journal of Translational Medicine<\/em> Vol 16, p 97 [Published\u00a0April 12, 2018]<\/p>\n

Background:<\/strong>
\nMyalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is\u00a0clinically defined and characterised by persistent disabling tiredness\u00a0and exertional malaise, leading to\u00a0 unctional impairment.<\/p>\n

Methods:<\/strong>
\nThis study introduces the weighted standing time (WST) as a proxy for\u00a0ME\/CFS severity, and investigates its behaviour in an Australian cohort.<\/p>\n

WST was calculated from standing time and subjective standing difficulty\u00a0data, collected via orthostatic intolerance assessments. The\u00a0distribution of WST for healthy controls and ME\/CFS patients was\u00a0correlated with the clinical criteria, as well as pathology and cytokine\u00a0markers. Included in the WST cytokine analyses were activins A and B,\u00a0cytokines causally linked to inflammation, and previously demonstrated\u00a0to separate ME\/CFS from healthy controls.<\/p>\n

Forty-five ME\/CFS patients\u00a0were recruited from the CFS Discovery Clinic (Victoria) between 2011 and\u00a02013. Seventeen healthy controls were recruited concurrently and\u00a0identically assessed.<\/p>\n

Results:<\/strong>
\nWST distribution was significantly different between ME\/CFS participants\u00a0and controls, with six diagnostic criteria, five analytes and one\u00a0cytokine also significantly different when comparing severity via WST.<\/p>\n

On direct comparison of ME\/CFS to study controls, only serum activin B\u00a0was significantly elevated, with no significant variation observed for a\u00a0broad range of serum and urine markers, or other serum cytokines.<\/p>\n

Conclusions:<\/strong>
\nThe enhanced understanding of standing test behaviour to reflect\u00a0orthostatic intolerance as a ME\/CFS symptom, and the subsequent\u00a0calculation of WST, will encourage the greater implementation of this\u00a0simple test as a measure of ME\/CFS diagnosis, and symptom severity, to\u00a0the benefit of improved diagnosis and guidance for potential treatments.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Weighting of orthostatic intolerance time measurements with\u00a0standing difficulty score stratifies ME\/CFS symptom severity\u00a0and analyte detection, by\u00a0Alice M. Richardson, Don P. Lewis, Badia Kita, Helen\u00a0Ludlow, Nigel P. Groome, Mark P. Hedger, David M. de\u00a0Kretser, Brett A. Lidbury in Journal … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4348,4351,4352,4170,4357,4354,4355,4353,4356,492,3270,4349,4350],"class_list":["post-16173","post","type-post","status-publish","format-standard","hentry","category-news","tag-activins","tag-alice-m-richardson","tag-badia-kita","tag-biomarker","tag-david-m-de-kretser","tag-don-p-lewis","tag-helen-ludlow","tag-mark-p-hedger","tag-nigel-p-groome","tag-orthostatic-intolerance","tag-prof-brett-lidbury","tag-weighted-standing-time","tag-wst"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4cR","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=16173"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16173\/revisions"}],"predecessor-version":[{"id":16212,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16173\/revisions\/16212"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=16173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=16173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=16173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}