{"id":16694,"date":"2018-05-22T09:15:20","date_gmt":"2018-05-22T09:15:20","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=16694"},"modified":"2018-05-22T09:15:20","modified_gmt":"2018-05-22T09:15:20","slug":"the-putative-role-of-oxidative-inflammation-in-the-pathophysiology-of-sleep-dysfunction-across-neuropsychiatric-disorders","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/the-putative-role-of-oxidative-inflammation-in-the-pathophysiology-of-sleep-dysfunction-across-neuropsychiatric-disorders\/","title":{"rendered":"The putative role of oxidative & inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders"},"content":{"rendered":"

Review summary:<\/strong><\/h3>\n

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis<\/a>, by Gerwyn Morris,\u00a0Brendon Stubbs, Cristiano A K\u00f6hlerx, Ken Walder, Anastasiya Slyepchenko, Michael Berk, Andr\u00e9 F. Carvalho in<\/span> Sleep Medicine Reviews <\/em>[Published online: April 04, 2018]<\/p>\n

Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse neuro-immune diseases, and may aggravate the course of several neuropsychiatric disorders. The underlying pathophysiology of sleep abnormalities across neuropsychiatric disorders remains unclear, and may involve the inter-play of several clinical variables and mechanistic pathways.<\/p>\n

In this review, we propose a heuristic<\/a> framework in which reciprocal interactions<\/a> of immune, oxidative and nitrosative stress, and mitochondrial pathways may drive sleep abnormalities across potentially neuroprogressive disorders. Specifically, it is proposed that systemic inflammation may activate microglial cells<\/a> and astrocytes<\/a> in\u00a0brain regions involved in sleep and circadian regulation.<\/p>\n

Activated glial cells may secrete pro-inflammatory cytokines (for example, interleukin-1 beta and tumour necrosis factor alpha), nitric oxide and gliotransmitters, which may influence the expression of key circadian regulators (e.g., the Circadian Locomotor Output Cycles Kaput<\/a> (CLOCK) gene). Furthermore, sleep disruption may further aggravate oxidative and nitrosative, peripheral immune activation, and (neuro) inflammation across these disorders in a vicious pathophysiological loop.<\/p>\n

\"\"<\/p>\n

This review will focus on chronic fatigue syndrome, bipolar disorder, and multiple sclerosis as exemplars of neuro-immune disorders. We conclude that novel therapeutic targets exploring immune and oxidative & nitrosative pathways (p.e. melatonin and molecular hydrogen) hold promise in alleviating sleep and circadian dysfunction in these disorders.<\/p>\n

Read full paper<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Review summary: The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis, by Gerwyn Morris,\u00a0Brendon Stubbs, Cristiano A K\u00f6hlerx, Ken Walder, Anastasiya Slyepchenko, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4432,447,556,783,306,65],"class_list":["post-16694","post","type-post","status-publish","format-standard","hentry","category-news","tag-bipolar-disorder","tag-inflammation","tag-ms","tag-multiple-sclerosis","tag-oxidative-stress","tag-sleep"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4lg","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=16694"}],"version-history":[{"count":2,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16694\/revisions"}],"predecessor-version":[{"id":16699,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16694\/revisions\/16699"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=16694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=16694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=16694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}