{"id":16722,"date":"2018-05-30T22:05:36","date_gmt":"2018-05-30T22:05:36","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=16722"},"modified":"2019-02-13T22:06:33","modified_gmt":"2019-02-13T22:06:33","slug":"transient-receptor-potential-ion-channels-in-the-etiology-pathomechanism-of-cfs-me","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/transient-receptor-potential-ion-channels-in-the-etiology-pathomechanism-of-cfs-me\/","title":{"rendered":"Transient Receptor Potential Ion channels in the etiology &#038; pathomechanism of CFS\/ME"},"content":{"rendered":"<h3><strong>Research abstract:<\/strong><\/h3>\n<p><a href=\"http:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=84678\" target=\"_blank\" rel=\"noopener\">Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis<\/a>, by Donald Staines, S Du Preez, H Cabanas, C Balinas, N Eaton, R Passmore, R Maksoud, J Redmayne, S Marshall-Gradisnik <span style=\"text-decoration: underline;\">in \u00a0<\/span><em>International Journal of Clinical Medicine<\/em>, May 2018\u00a0 9:5, 445-453.<\/p>\n<p>Chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME) is a disabling condition of unknown cause having multi-system manifestations.<\/p>\n<p>Our group has investigated the potential role of transient receptor potential (TRP) ion channels in the etiology and pathomechanism of this illness. Store-operated calcium entry (SOCE) signaling is the primary intracellular calcium signaling mechanism in non-excitable cells and is associated with TRP ion channels.<\/p>\n<p>While the sub-family (Canonical) TRPC has been traditionally associated with this important cellular mechanism, a member of the TRPM sub-family group (Melastatin), TRPM3, has also been recently identified as participating in SOCE in white matter of the central nervous system.<\/p>\n<p>We have identified single nucleotide polymorphisms (SNPs) in TRP genes in natural killer (NK) cells and peripheral blood mononuclear cells (PBMCs) in CFS\/ME patients. We also describe biochemical pathway changes and calcium signaling perturbations in blood cells from patients. The ubiquitous distribution of TRP ion channels and specific locations of sub-family group members such as TRPM3 suggest a contribution to systemic pathology in CFS\/ME.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research abstract: Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis, by Donald Staines, S Du Preez, H Cabanas, C Balinas, N Eaton, R Passmore, R Maksoud, J Redmayne, S Marshall-Gradisnik in \u00a0International Journal &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/transient-receptor-potential-ion-channels-in-the-etiology-pathomechanism-of-cfs-me\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4452,4305,230,229,1249,4308,4447,4307,2676,4448,4449,4450,4451],"class_list":["post-16722","post","type-post","status-publish","format-standard","hentry","category-news","tag-calcium-signaling","tag-cassandra-balinas","tag-central-nervous-system","tag-cns","tag-dr-sonya-marshall-gradisnik","tag-helene-cabanas","tag-j-redmayne","tag-natalie-eaton","tag-prof-donald-staines","tag-r-maksoud","tag-r-passmore","tag-s-du-preez","tag-transient-receptor-potential-ion-channels"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4lI","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16722","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=16722"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16722\/revisions"}],"predecessor-version":[{"id":16894,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16722\/revisions\/16894"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=16722"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=16722"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=16722"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}