{"id":16926,"date":"2018-06-12T07:43:40","date_gmt":"2018-06-12T07:43:40","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=16926"},"modified":"2018-06-12T08:08:12","modified_gmt":"2018-06-12T08:08:12","slug":"cortical-hypoactivation-during-resting-eeg-suggests-central-nervous-system-pathology-in-patients-with-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/cortical-hypoactivation-during-resting-eeg-suggests-central-nervous-system-pathology-in-patients-with-cfs\/","title":{"rendered":"Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with CFS"},"content":{"rendered":"

Research abstract:<\/strong><\/p>\n

Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome<\/a>, by\u00a0MA Zinn, ML Zinna, I Valencia, LA Jason, JG Montoya\u00a0in<\/span>\u00a0Biological Psychology\u00a0Vol 136,\u00a0July 2018, Pages 87-99<\/p>\n

We investigated central fatigue in 50 patients with\u00a0chronic fatigue syndrome\u00a0(CFS) and 50 matched healthy controls (HC).<\/p>\n

Resting state EEG<\/a> was collected from 19 scalp locations during a 3\u202fmin, eyes-closed condition. Current densities were localized using exact low-resolution electromagnetic tomography (eLORETA).<\/p>\n

The Multidimensional Fatigue Inventory<\/a> (MFI-20) and the Fatigue Severity Scale<\/a> (FSS) were administered to all participants. Independent\u00a0t-tests and linear regression analyses were used to evaluate group differences in current densities, followed by statistical non-parametric mapping (SnPM) correction procedures.<\/p>\n

\"\"Significant differences were found in the delta (1\u20133\u202fHz) and beta-2 (19\u201321\u202fHz) frequencybands. Delta sources were found predominately in the\u00a0frontal lobe<\/a>, while beta-2 sources were found in the medial and superior\u00a0parietal lobe<\/a>. Left-lateralized, frontal delta sources were associated with a clinical reduction in motivation.<\/p>\n

The implications of abnormal cortical sources in patients with CFS are discussed.<\/p>\n

5. Conclusions
\nOverall, the present study revealed a pattern of global central nervous\u00a0system hypoactivation in patients with CFS. Most research points\u00a0to a common finding of cognitive slowing in CFS and we identified this\u00a0with quantifiable increases in delta and decreases in beta-2 frequency\u00a0bands. Focal increases in delta sources in regions with language and\u00a0limbic underpinnings were related to a reduced motivation factor of
\nfatigue.<\/p>\n

Our findings add to the existing literature demonstrating evidence\u00a0of central nervous system involvement in patients with CFS.<\/p>\n

Identifying the subtle aspects of brain dysfunction underscores the need\u00a0for studies of CFS examining EEG signals that reflect cellular electrical\u00a0conductivity without time-delay and different frequency bands for\u00a0added information about synchronous brain region activities.<\/p>\n

Finally,\u00a0our study demonstrates that eLORETA is a promising tool for recognizing\u00a0CFS pathogenesis in spatial locations of the brain on a time\u00a0scale of milliseconds (Pascual-Marqui et al., 2011; Zinn et al., 2016a)<\/p>\n

Read full paper<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Research abstract: Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome, by\u00a0MA Zinn, ML Zinna, I Valencia, LA Jason, JG Montoya\u00a0in\u00a0Biological Psychology\u00a0Vol 136,\u00a0July 2018, Pages 87-99 We investigated central fatigue in 50 patients … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[230,1038,2415,4152,4477,1828,3920,1004,2456,723,4012,2241],"class_list":["post-16926","post","type-post","status-publish","format-standard","hentry","category-news","tag-central-nervous-system","tag-cortical-pathology","tag-eeg","tag-eloreta","tag-exact-low-resolution-electromagnetic-tomography","tag-fss","tag-ian-valencia","tag-marcie-zinn","tag-mark-a-zinn","tag-mfi-scales","tag-prof-jose-montoya","tag-prof-leonard-jason"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4p0","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=16926"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16926\/revisions"}],"predecessor-version":[{"id":16991,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/16926\/revisions\/16991"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=16926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=16926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=16926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}