{"id":17772,"date":"2018-08-24T09:16:47","date_gmt":"2018-08-24T09:16:47","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=17772"},"modified":"2018-11-12T20:39:33","modified_gmt":"2018-11-12T20:39:33","slug":"hyperintense-sensorimotor-t1-spin-echo-mri-is-associated-with-brainstem-abnormality-in-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/hyperintense-sensorimotor-t1-spin-echo-mri-is-associated-with-brainstem-abnormality-in-cfs\/","title":{"rendered":"Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in CFS"},"content":{"rendered":"

Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in CFS <\/a>by Leighton R. Barnden, Zack Y. Shan, Donald R Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep Bhuta,\u00a0in<\/span>\u00a0NeuroImage: Clinical\u00a0<\/em>Volume 20,\u00a02018, Pages 102-109<\/h3>\n

Research abstract:<\/strong>
\nWe recruited 43\u00a0Chronic Fatigue Syndrome\u00a0(CFS) subjects who met Fukuda criteria and 27 healthy controls and performed\u00a03T MRI\u00a0T1 and T2 weighted spin-echo (T1wSE and T2wSE) scans. T1wSE signal follows\u00a0T1 relaxation\u00a0rate (1\/T1 relaxation time) and responds to\u00a0myelin\u00a0and iron (ferritin) concentrations.<\/p>\n

We performed\u00a0MRI\u00a0signal level group comparisons with SPM12.\u00a0Spatial\u00a0 normalization after segmentation was performed using T2wSE scans and applied to the coregistered T1wSE scans.<\/p>\n

After global signal-level normalization of individual scans, the T1wSE group comparison detected\u00a0decreased\u00a0signal-levels in CFS in a\u00a0brainstem\u00a0region (cluster-based inference controlled for family wise error rate,\u00a0PFWE=\u00a00.002), and\u00a0increased\u00a0signal-levels in large bilateral clusters in sensorimotor cortex\u00a0white matter\u00a0(cluster\u00a0PFWE\u00a0< 0.0001). Moreover, the brainstem T1wSE values were negatively correlated with the sensorimotor values for both CFS (R2\u00a0= 0.31, P = 0.00007) and healthy controls (R2\u00a0= 0.34, P = 0.0009), and the regressions were co-linear.<\/p>\n

This relationship, previously unreported in either healthy controls or CFS, in view of known thalamic projection-fibre plasticity, suggests brainstem conduction<\/a> deficits in CFS may stimulate the upregulation of myelin<\/a> in the sensorimotor cortex<\/a> to maintain brainstem \u2013 sensorimotor connectivity.<\/p>\n

VBM did not find group differences in regional\u00a0grey matter\u00a0or white matter volumes. We argued that increased T1wSE observed in sensorimotor WM in CFS indicates increased myelination which is a regulatory response to deficits in the brainstem although the causality cannot be tested in this study.<\/p>\n

Altered brainstem myelin may have broad consequences for cerebral function and should be a focus of future research.<\/p>\n","protected":false},"excerpt":{"rendered":"

Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in CFS by Leighton R. Barnden, Zack Y. Shan, Donald R Staines, Sonya Marshall-Gradisnik, Kevin Finegan, Timothy Ireland, Sandeep Bhuta,\u00a0in\u00a0NeuroImage: Clinical\u00a0Volume 20,\u00a02018, Pages 102-109 Research abstract: We recruited 43\u00a0Chronic … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[2572,3495,1249,4418,1037,2676,4582,4420,3875],"class_list":["post-17772","post","type-post","status-publish","format-standard","hentry","category-news","tag-brainstem","tag-dr-leighton-barnden","tag-dr-sonya-marshall-gradisnik","tag-kevin-finegan","tag-mri","tag-prof-donald-staines","tag-sandeep-bhuta","tag-timothy-ireland","tag-zack-y-shan"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4CE","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=17772"}],"version-history":[{"count":5,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17772\/revisions"}],"predecessor-version":[{"id":18592,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17772\/revisions\/18592"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=17772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=17772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=17772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}