{"id":17774,"date":"2018-09-07T06:59:04","date_gmt":"2018-09-07T06:59:04","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=17774"},"modified":"2018-09-07T07:06:10","modified_gmt":"2018-09-07T07:06:10","slug":"cardiopulmonary-exercise-test-methodology-for-assessing-exertion-intolerance-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/cardiopulmonary-exercise-test-methodology-for-assessing-exertion-intolerance-in-me-cfs\/","title":{"rendered":"Cardiopulmonary exercise test methodology for assessing exertion intolerance in ME\/CFS"},"content":{"rendered":"

Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in ME\/CFS<\/a> by Staci Stevens, Chris Snell, Jared Stevens, Betsy Keller and J Mark VanNess in<\/span>\u00a0Frontiers in Pediatrics,\u00a0<\/em>4 September 2018<\/p>\n

Background<\/strong>:<\/p>\n

\"\"Concise methodological directions for administration of serial cardiopulmonary exercise testing (CPET) are needed for testing of patients with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS). Maximal CPET is used to evaluate the coordinated metabolic, muscular, respiratory and cardiac contributions to energy production in patients with ME\/CFS.<\/p>\n

In this patient population, CPET also elicits a robust post-exertional symptom flare (termed, post-exertional malaise); a cardinal symptom of the disease. CPET measures are highly reliable and reproducible in both healthy and diseased populations. However, evidence to date indicates that ME\/CFS patients are uniquely unable to reproduce CPET measures during a second test, despite giving maximal effort during both tests, due to the effects of PEM on energy production.<\/p>\n

Methodology:<\/strong><\/p>\n

To document and assess functional impairment due to the effects of post-exertional malaise in ME\/CFS, a 2-day CPET procedure (2-day CPET) has been used to first measure baseline functional capacity (CPET1) and provoke post-exertional malaise, then assess changes in CPET variables 24 h later with a second CPET to assess the effects of post-exertional malaise on functional capacity.<\/p>\n

The second CPET measures changes in energy production and physiological function, objectively documenting the effects of post-exertional malaise. Use of CPET as a standardized stressor to induce post-exertional malaise and quantify impairment associated with post-exertional malaise has been employed to examine ME\/CFS pathology in several studies.<\/p>\n

This article discusses the results of those studies, as well as the standardized techniques and procedures for use of the 2-day CPET in ME\/CFS patients, and potentially other fatiguing illnesses.<\/p>\n

Conclusions<\/strong>:<\/p>\n

Basic concepts of CPET are summarized, and special considerations for performing CPET on ME\/CFS patients are detailed to ensure a valid outcome. The 2-day CPET methodology is outlined, and the utility of the procedure is discussed for assessment of functional capacity and exertion intolerance in ME\/CFS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in ME\/CFS by Staci Stevens, Chris Snell, Jared Stevens, Betsy Keller and J Mark VanNess in\u00a0Frontiers in Pediatrics,\u00a04 September 2018 Background: Concise methodological directions for administration of serial cardiopulmonary exercise testing (CPET) … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[3049,3184,516,4606,4605,4604,584,585,654,2074],"class_list":["post-17774","post","type-post","status-publish","format-standard","hentry","category-news","tag-2-day-cpet","tag-betsy-a-keller","tag-cardiopulmonary-exercise-testing","tag-chris-snell","tag-exertion-intolerance","tag-jared-stevens","tag-pem","tag-post-exertional-malaise","tag-prof-mark-vanness","tag-staci-r-stevens"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4CG","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=17774"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17774\/revisions"}],"predecessor-version":[{"id":17982,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17774\/revisions\/17982"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=17774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=17774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=17774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}