{"id":17961,"date":"2018-09-05T09:44:46","date_gmt":"2018-09-05T09:44:46","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=17961"},"modified":"2018-09-05T09:44:46","modified_gmt":"2018-09-05T09:44:46","slug":"responses-in-bmj-to-prof-sharpe-on-pace-trial","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/responses-in-bmj-to-prof-sharpe-on-pace-trial\/","title":{"rendered":"Responses in BMJ to Prof Sharpe on PACE trial"},"content":{"rendered":"

\u00a0Pressure grows on\u00a0Lancet\u00a0to review \u201cflawed\u201d PACE trial<\/a><\/h2>\n

\"\"On 22 August Ingrid Torjesen\u00a0<\/strong> wrote a news item in the British Medical Journal about an article in the Times which highlighted the call to review the results of the PACE trial into Graded Exercise Therapy and Cognitive Behavioural Therapy for CFS\/ME.<\/p>\n

Prof Michael Sharpe,<\/strong> one of the PACE trial researchers, responded supporting the trial:\u00a0Re: Odd piece in Times newspaper about pressure on the Lancet to review unwelcome PACE trial findings<\/a><\/p>\n

Science does not progress by campaigners trying to stop research being done or by suppressing its findings, simply because they are unwelcome. Science works best by testing ideas by doing experiments and then seeking either replication or refutation of the findings; the PACE trial findings have so far been replicated a number of times. We look forward to them being subject to further testing by other researchers in future.<\/p>\n

Jonathan R Kerr,<\/strong> consultant in Microbiology at West sussex Hospital responded:\u00a0We can specifically treat several infective CFS\/ME subtypes<\/a><\/p>\n

Jim Ellsworth<\/strong>: No difference at long term followup<\/a><\/p>\n

Prof Jonathan CW Edwards<\/strong>:\u00a0Inaccurate remarks by Professor Sharpe<\/a><\/p>\n

Prof Jonathan CW Edwards:\u00a0<\/strong>Re: Pressure grows on Lancet to review \u201cflawed\u201d PACE trial<\/a><\/p>\n

The reason why I have signed the letter to The Lancet is that the PACE trial is methodologically so poor as to be uninterpretable.<\/p>\n

Barbara Robinson<\/strong>:\u00a0PACE proponents, straw men and bricks.<\/a><\/p>\n

Nasim Marie Jafry<\/strong>:\u00a0Re: Pressure grows on Lancet to review \u201cflawed\u201d PACE trial<\/p>\n

In reality, many ME patients have been made worse by graded exercise, which is unsurprising as exertion intolerance is at the core of ME.<\/p>\n

Dr Ellen CG Grant<\/strong>:\u00a0Mitochondrial dysfunction in ME\/CFS needs testing and treating Re: Pressure grows on Lancet to review \u201cflawed\u201d PACE trial<\/a><\/p>\n

Andrew J Keeley<\/strong>:\u00a0Please do not misunderstand patient views<\/a><\/p>\n

Patients were angry that the results of the trial were excessively spun, and that much of the outcome measures specified in the protocol were not reported in the manuscript published in The Lancet. In particular, the thresholds for “positive outcome” and “recovery” were heavily watered down such that they were no longer meaningful.<\/p>\n

Read all responses<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0Pressure grows on\u00a0Lancet\u00a0to review \u201cflawed\u201d PACE trial On 22 August Ingrid Torjesen\u00a0 wrote a news item in the British Medical Journal about an article in the Times which highlighted the call to review the results of the PACE trial into … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[66,3843,1499,2537,906,310,571,2150],"class_list":["post-17961","post","type-post","status-publish","format-standard","hentry","category-news","tag-bmj","tag-dr-ellen-cg-grant","tag-ingrid-torjesen","tag-jonathan-kerr","tag-nasim-marie-jafry","tag-pace-trial","tag-prof-jonathan-edwards","tag-prof-michael-sharpe"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4FH","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=17961"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17961\/revisions"}],"predecessor-version":[{"id":17967,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/17961\/revisions\/17967"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=17961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=17961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=17961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}