{"id":18588,"date":"2018-11-15T07:28:53","date_gmt":"2018-11-15T07:28:53","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=18588"},"modified":"2018-11-15T07:28:53","modified_gmt":"2018-11-15T07:28:53","slug":"low-omega-3-index-polyunsaturated-fatty-acid-status-in-patients-with-cfs-me","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/low-omega-3-index-polyunsaturated-fatty-acid-status-in-patients-with-cfs-me\/","title":{"rendered":"Low omega-3 index &#038; polyunsaturated fatty acid status in patients with CFS\/ME"},"content":{"rendered":"<h3><a href=\"https:\/\/www.plefa.com\/article\/S0952-3278(18)30053-X\/abstract\" target=\"_blank\" rel=\"noopener\">Low omega-3 index and polyunsaturated fatty acid status in patients with Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis<\/a>, by\u00a0Jes\u00fas Castro-Marrero,\u00a0Joan Carles Domingo, Alba Martinez-Martinez, Jos\u00e9 Alegre,\u00a0Clemens von Schacky<span style=\"text-decoration: underline;\"> in<\/span>\u00a0<em>Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)<\/em> [Published online: November 9, 2018]<\/h3>\n<p><strong>Highlights:<\/strong><\/p>\n<ul>\n<li><img data-recalc-dims=\"1\" decoding=\"async\" class=\"size-medium wp-image-18589 alignright lazyload\" data-src=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2018\/11\/Omega-3-300x266.jpg?resize=300%2C266\" alt=\"\" width=\"300\" height=\"266\" data-srcset=\"https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2018\/11\/Omega-3.jpg?resize=300%2C266&amp;ssl=1 300w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2018\/11\/Omega-3.jpg?resize=150%2C133&amp;ssl=1 150w, https:\/\/i0.wp.com\/wames.org.uk\/cms-english\/wp-content\/uploads\/2018\/11\/Omega-3.jpg?w=464&amp;ssl=1 464w\" data-sizes=\"(max-width: 300px) 100vw, 300px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/266;\" \/>Erythrocyte omega-3 index (5.75%) and n-3 PUFA levels are low in individuals with CFS\/ME.<\/li>\n<li>The erythrocyte omega-3 index may be a useful biomarker of overall health, but cut-off points need be validated in the Spanish CFS\/ME population.<\/li>\n<li>This study suggests that low EPA\u202f+\u202fDHA levels may be a risk factor for poor cardiovascular health and pro-inflammatory status in CFS\/ME. Understanding the role of omega-3 PUFAs and immunometabolism should be the next step.<\/li>\n<li>Further studies of omega-3 fatty acid supplementation in CFS\/ME are warranted.<\/li>\n<\/ul>\n<p><strong>Research abstract:<\/strong><\/p>\n<p>Background:<br \/>\nSeveral studies have suggested that low levels of omega-3 fatty acids (n-3 PUFAs) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with cardiovascular risk, major depression, sleep problems, inflammation and other health-related issues. So far, however, erythrocyte PUFA status in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis (CFS\/ME) has not been established. This study aimed to determine whether n-3 PUFA content and omega-3 index are associated with measures in CFS\/ME patients.<\/p>\n<p>Patients and Methods:<br \/>\nPUFA levels and omega-3 index were measured in 31 Spanish CFS\/ME patients using the HS-Omega-3 Index\u00ae method. Demographic and clinical characteristics and self-reported outcome measures were also recorded.<\/p>\n<p>Results:<br \/>\nA low mean omega-3 index (5.75%) was observed in 92.6% of the sample. Omega-3 index was inversely correlated with the AA\/EPA ratio (p= 0.00002) and the BMI (p= 0.0106). In contrast, the AA\/EPA ratio was positively associated with the BMI (p= 0.0038). No association for FIS-40 and PSQI measures was found (p&gt; 0.05).<\/p>\n<p>Conclusion:<br \/>\nThe low omega-3 index found in our CFS\/ME patients may indicate increased risks for cardiovascular health, which should be further investigated. A low omega-3 index also suggests a pro-inflammatory state in these patients. Attempts should be made to increase the omega-3 index in CFS\/ME patients, based on intervention trials assessing a potential therapeutic value.<\/p>\n<p><a href=\"https:\/\/sci-hub.tw\/10.1016\/j.plefa.2018.11.006\" target=\"_blank\" rel=\"noopener\">Read full article<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Low omega-3 index and polyunsaturated fatty acid status in patients with Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis, by\u00a0Jes\u00fas Castro-Marrero,\u00a0Joan Carles Domingo, Alba Martinez-Martinez, Jos\u00e9 Alegre,\u00a0Clemens von Schacky in\u00a0Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) [Published online: November 9, 2018] Highlights: Erythrocyte omega-3 &hellip; <a href=\"https:\/\/wames.org.uk\/cms-english\/low-omega-3-index-polyunsaturated-fatty-acid-status-in-patients-with-cfs-me\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[4290,1250,4704,447,4284,4703,4289,4702,4705],"class_list":["post-18588","post","type-post","status-publish","format-standard","hentry","category-news","tag-alba-martinez-martinez","tag-cardiovascular-function","tag-clemens-von-schacky","tag-inflammation","tag-jesus-castro-marrero","tag-joan-carles-domingo","tag-jose-alegre","tag-omega-3-index","tag-polyunsaturated-fatty-acids"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4PO","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/18588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=18588"}],"version-history":[{"count":1,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/18588\/revisions"}],"predecessor-version":[{"id":18590,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/18588\/revisions\/18590"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=18588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=18588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=18588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}