{"id":18728,"date":"2018-12-06T08:24:13","date_gmt":"2018-12-06T08:24:13","guid":{"rendered":"http:\/\/wames.org.uk\/cms-english\/?p=18728"},"modified":"2018-12-06T08:24:13","modified_gmt":"2018-12-06T08:24:13","slug":"brain-abnormalities-in-me-cfs","status":"publish","type":"post","link":"https:\/\/wames.org.uk\/cms-english\/brain-abnormalities-in-me-cfs\/","title":{"rendered":"Brain abnormalities in ME\/CFS"},"content":{"rendered":"

Brain abnormalities in myalgic encephalomyelitis\/chronic fatigue\u00a0syndrome: Evaluation by diffusional kurtosis imaging and neurite\u00a0orientation dispersion and density imaging,<\/a> by\u00a0Kimura Y, Sato N, Ota M, Shigemoto Y, Morimoto E,\u00a0Enokizono M, Matsuda H, Shin I, Amano K, Ono H,\u00a0Sato W, Yamamura T in<\/span>\u00a0Journal of Magnetic Resonance Imaging<\/em>, 14 Nov 2018<\/p>\n

Research abstract:<\/strong><\/p>\n

Background:<\/strong>
\nDiffusional kurtosis imaging<\/a> (DKI) and neurite orientation dispersion\u00a0and density imaging<\/a> (NODDI) metrics provide more specific information\u00a0regarding pathological changes than diffusion tensor imaging (DTI).<\/p>\n

Purpose:<\/strong>
\n\"\"To detect microstructural abnormalities in myalgic encephalomyelitis\u00a0(ME) \/ chronic fatigue syndrome (CFS) patients by using DKI and NODDI\u00a0metrics.<\/p>\n

Study Type:<\/strong>
\nProspective.<\/p>\n

Population:<\/strong>
\nTwenty ME\/CFS patients and 23 healthy controls were recruited.<\/p>\n

Field Strength\/Sequence:<\/strong>
\nThree-b value DWI (b-values\u2009=\u20090, 1000, and 2000 sec\/mm2 ) and 3D T1\u00a0-weighted images were at 3.0T.<\/p>\n

Assessment:<\/strong>
\nMean kurtosis (MK), neurite density index (NDI), orientation dispersion\u00a0index (ODI), fractional anisotropy (FA), and mean diffusivity (MD) were\u00a0calculated.<\/p>\n

Statistical Testing:\u00a0<\/strong>
\nThe two-sample t-test analysis in SPM12 software was used to compare the\u00a0differences between ME\/CFS and control groups.<\/p>\n

Results:<\/strong>
\nIn the ME\/CFS patients, we observed significant FA decreases in the genu\u00a0of the corpus callosum and the anterior limb of the right internal\u00a0capsule (P\u2009<\u20090.05), but no significant difference in MD (P\u2009=\u20090.164);\u00a0there were also significant MK decreases in the right frontal area,\u00a0anterior cingulate gyrus, superior longitudinal fasciculus (SLF), and\u00a0left parietal area (P\u2009<\u20090.05). Significant NDI decreases were observed\u00a0in the right posterior cingulate gyrus, SLF, and left frontal area of\u00a0the ME\/CFS patients (P\u2009<\u20090.05). Significant ODI decreases were seen in\u00a0the bilateral occipital areas, right superior temporal gyrus, the\u00a0anterior limb of internal capsule, and the posterior cingulate gyrus\u00a0(P\u2009<\u20090.05), and significant ODI increases were revealed in the bilateral\u00a0occipital and right temporal areas (P\u2009<\u20090.05).<\/p>\n

Data Conclusion:<\/strong>
\nRight SLF abnormalities may be a diagnostic marker for ME\/CFS.<\/p>\n

Level of Evidence:<\/strong>
\n1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.<\/p>\n

Read the full article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Brain abnormalities in myalgic encephalomyelitis\/chronic fatigue\u00a0syndrome: Evaluation by diffusional kurtosis imaging and neurite\u00a0orientation dispersion and density imaging, by\u00a0Kimura Y, Sato N, Ota M, Shigemoto Y, Morimoto E,\u00a0Enokizono M, Matsuda H, Shin I, Amano K, Ono H,\u00a0Sato W, Yamamura T in\u00a0Journal … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[392,394,4747,4748,1037,4743,4746,4745,4744,759],"class_list":["post-18728","post","type-post","status-publish","format-standard","hentry","category-news","tag-brain-dysfunction","tag-brain-inflammation","tag-diffusional-kurtosis-imaging","tag-dki","tag-mri","tag-n-sato","tag-noddi","tag-t-yamamura","tag-y-kimura","tag-yasuyoshi-watanabe"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5qkYK-4S4","_links":{"self":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/18728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/comments?post=18728"}],"version-history":[{"count":3,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/18728\/revisions"}],"predecessor-version":[{"id":18851,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/posts\/18728\/revisions\/18851"}],"wp:attachment":[{"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/media?parent=18728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/categories?post=18728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wames.org.uk\/cms-english\/wp-json\/wp\/v2\/tags?post=18728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}